Redox-Responsive Nanoparticles from the Single Disulfide Bond-Bridged Block Copolymer as Drug Carriers for Overcoming Multidrug Resistance in Cancer Cells

• Published in: Bioconjugate chemistry Vol. 22; no. 10; pp. 1939 - 1945
• Main Authors: Wang, Yu-Cai, Wang, Feng, Sun, Tian-Meng, Wang, Jun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.10.2011
• Subjects: Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - pharmacology; Breast Neoplasms - drug therapy; Cancer; Cell Line, Tumor; Cells; Chemical bonds; Copolymers; Cytotoxicity; Disulfides - chemistry; Doxorubicin - administration & dosage; Doxorubicin - pharmacology; Drug Carriers - chemistry; Drug resistance; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Nanoparticles; Nanoparticles - chemistry; Oxidation-Reduction; Polyesters - chemistry; Polymers; Retention

Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. The intracellular accumulation of drug and the intracellular release of drug molecules from the carrier could be the most important barriers for nanoscale carriers in overcoming MDR. We demonstrated that the redo...