A Wrench-Shaped Synthetic Molecule that Modulates a Transcription Factor−Coactivator Interaction
Development of synthetic molecules that provide external control over the transcription of a given gene represents a challenge in medicinal and bioorganic chemistry. Here we report design and analysis of wrenchnolol, a wrench-shaped synthetic molecule that impairs the transcription of the Her2 oncog...
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Published in | Journal of the American Chemical Society Vol. 126; no. 11; pp. 3461 - 3471 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
24.03.2004
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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