Dopamine reuptake site densities in patients with social phobia
OBJECTIVE: It has been suggested that social phobia is associated with dysfunction of the noradrenergic and dopaminergic systems, but there are no published anatomic data on the monoaminergic abnormalities found in the brains of phobic patients. The authors studied the density of dopamine reuptake s...
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| Published in | The American journal of psychiatry Vol. 154; no. 2; pp. 239 - 242 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Psychiatric Publishing
01.02.1997
American Psychiatric Association |
| Subjects | |
| Online Access | Get full text |
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| Abstract | OBJECTIVE: It has been suggested that social phobia is associated with
dysfunction of the noradrenergic and dopaminergic systems, but there are no
published anatomic data on the monoaminergic abnormalities found in the
brains of phobic patients. The authors studied the density of dopamine
reuptake sites in patients with social phobia. METHOD: The study included
11 patients with social phobia and 28 healthy comparison subjects, 11 of
whom were age- and gender-matched to the patients for the analyses.
Measurement of the density of dopamine reuptake sites was performed by
using a 123I-labeled cocaine analogue, [123I]beta-CIT, with single photon
emission computed tomography (SPECT). RESULTS: Blind quantitative analysis
revealed that striatal dopamine reuptake site densities were markedly lower
in the patients with social phobia than in the age- and gender-matched
comparison subjects. CONCLUSIONS: The results indicate that social phobia
may be associated with a dysfunction of the striatal dopaminergic
system. |
|---|---|
| AbstractList | OBJECTIVE: It has been suggested that social phobia is associated with
dysfunction of the noradrenergic and dopaminergic systems, but there are no
published anatomic data on the monoaminergic abnormalities found in the
brains of phobic patients. The authors studied the density of dopamine
reuptake sites in patients with social phobia. METHOD: The study included
11 patients with social phobia and 28 healthy comparison subjects, 11 of
whom were age- and gender-matched to the patients for the analyses.
Measurement of the density of dopamine reuptake sites was performed by
using a 123I-labeled cocaine analogue, [123I]beta-CIT, with single photon
emission computed tomography (SPECT). RESULTS: Blind quantitative analysis
revealed that striatal dopamine reuptake site densities were markedly lower
in the patients with social phobia than in the age- and gender-matched
comparison subjects. CONCLUSIONS: The results indicate that social phobia
may be associated with a dysfunction of the striatal dopaminergic
system. It has been suggested that social phobia is associated with dysfunction of the noradrenergic and dopaminergic systems, but there are no published anatomic data on the monoaminergic abnormalities found in the brains of phobic patients. The authors studied the density of dopamine reuptake sites in patients with social phobia.OBJECTIVEIt has been suggested that social phobia is associated with dysfunction of the noradrenergic and dopaminergic systems, but there are no published anatomic data on the monoaminergic abnormalities found in the brains of phobic patients. The authors studied the density of dopamine reuptake sites in patients with social phobia.The study included 11 patients with social phobia and 28 healthy comparison subjects, 11 of whom were age- and gender-matched to the patients for the analyses. Measurement of the density of dopamine reuptake sites was performed by using a 123I-labeled cocaine analogue, [123I]beta-CIT, with single photon emission computed tomography (SPECT).METHODThe study included 11 patients with social phobia and 28 healthy comparison subjects, 11 of whom were age- and gender-matched to the patients for the analyses. Measurement of the density of dopamine reuptake sites was performed by using a 123I-labeled cocaine analogue, [123I]beta-CIT, with single photon emission computed tomography (SPECT).Blind quantitative analysis revealed that striatal dopamine reuptake site densities were markedly lower in the patients with social phobia than in the age- and gender-matched comparison subjects.RESULTSBlind quantitative analysis revealed that striatal dopamine reuptake site densities were markedly lower in the patients with social phobia than in the age- and gender-matched comparison subjects.The results indicate that social phobia may be associated with a dysfunction of the striatal dopaminergic system.CONCLUSIONSThe results indicate that social phobia may be associated with a dysfunction of the striatal dopaminergic system. It has been suggested that social phobia is associated with dysfunction of the noradrenergic and dopaminergic systems, but there are no published anatomic data on the monoaminergic abnormalities found in the brains of phobic patients. The authors studied the density of dopamine reuptake sites in patients with social phobia. The study included 11 patients with social phobia and 28 healthy comparison subjects, 11 of whom were age- and gender-matched to the patients for the analyses. Measurement of the density of dopamine reuptake sites was performed by using a 123I-labeled cocaine analogue, [123I]beta-CIT, with single photon emission computed tomography (SPECT). Blind quantitative analysis revealed that striatal dopamine reuptake site densities were markedly lower in the patients with social phobia than in the age- and gender-matched comparison subjects. The results indicate that social phobia may be associated with a dysfunction of the striatal dopaminergic system. It has been suggested that social phobia is associated with dysfunction of the noradrenergic and dopaminergic systems, but there are no published anatomic data on the monoaminergic abnormalities found in the brains of phobic patients. The authors studied the density of dopamine reuptake sites in patients with social phobia. The study included 11 patients with social phobia and 28 healthy comparison subjects, 11 of whom were age- and gender-matched to the patients for the analyses. Measurement of the density of dopamine reuptake sites was performed by using a 123I-labeled cocaine analogue, [123I]beta-CIT, with single photon emission computed tomography (SPECT). Blind quantitative analysis revealed that striatal dopamine reuptake site densities were markedly lower in the patients with social phobia than in the age- and gender-matched comparison subjects. The results indicate that social phobia may be associated with a dysfunction of the striatal dopaminergic system. |
| Author | TIIHONEN, J BERGSTRÖM, K LEPOLA, U KUIKKA, J LEINONEN, E KOPONEN, H |
| Author_xml | – sequence: 1 givenname: J surname: TIIHONEN fullname: TIIHONEN, J organization: Department of Clinical Psychiatry, University of Kuopio, Finland – sequence: 2 givenname: J surname: KUIKKA fullname: KUIKKA, J organization: Department of Clinical Psychiatry, University of Kuopio, Finland – sequence: 3 givenname: K surname: BERGSTRÖM fullname: BERGSTRÖM, K organization: Department of Clinical Psychiatry, University of Kuopio, Finland – sequence: 4 givenname: U surname: LEPOLA fullname: LEPOLA, U organization: Department of Clinical Psychiatry, University of Kuopio, Finland – sequence: 5 givenname: H surname: KOPONEN fullname: KOPONEN, H organization: Department of Clinical Psychiatry, University of Kuopio, Finland – sequence: 6 givenname: E surname: LEINONEN fullname: LEINONEN, E organization: Department of Clinical Psychiatry, University of Kuopio, Finland |
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| Cites_doi | 10.1002/syn.890160203 10.1016/0278-5846(92)90020-F 10.1097/00006231-199306000-00013 10.1038/ng0196-78 10.1007/BF00941852 10.1016/0166-2236(92)90068-J 10.1001/archpsyc.1994.03950120047008 10.1038/ng0196-81 10.1001/archpsyc.1994.03950080019003 10.1176/ajp.138.12.1572 10.1001/archpsyc.1994.03950010008002 10.1007/BF01245007 10.1007/BF00182306 10.1097/00004714-198604000-00006 10.1097/00004714-198808000-00008 10.1038/nm0795-654 10.1038/jcbfm.1993.39 10.1192/bjp.161.3.353 10.1001/archpsyc.1984.01790210041006 10.1073/pnas.90.24.11965 10.1037/e591322011-001 10.1016/1353-8020(95)00012-U 10.1007/BF00180909 |
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| Keywords | Human Dopamine Reuptake site Social phobia Central nervous system Anxiety disorder Neurotransmitter Corpus striatum Brain (vertebrata) |
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dysfunction of the noradrenergic and dopaminergic systems, but there are no
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| SubjectTerms | Adult Adult and adolescent clinical studies Aged Anxiety disorders. Neuroses Biological and medical sciences Brain Brain - diagnostic imaging Brain Chemistry Carrier Proteins - metabolism Cocaine - analogs & derivatives Corpus Striatum - chemistry Corpus Striatum - diagnostic imaging Dopamine - analysis Dopamine Plasma Membrane Transport Proteins Dopamine Uptake Inhibitors - therapeutic use Fear & phobias Female Humans Male Medical sciences Membrane Glycoproteins Membrane Transport Proteins Middle Aged Nerve Tissue Proteins Neurology Neurons Phobia Phobic Disorders - diagnosis Phobic Disorders - diagnostic imaging Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Tomography, Emission-Computed, Single-Photon |
| Title | Dopamine reuptake site densities in patients with social phobia |
| URI | http://dx.doi.org/10.1176/ajp.154.2.239 https://www.ncbi.nlm.nih.gov/pubmed/9016274 https://www.proquest.com/docview/1518329982 https://www.proquest.com/docview/220473462 https://www.proquest.com/docview/78810947 |
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