Pb EXAFS Studies on DNA Quadruplexes:  Identification of Metal Ion Binding Site

• Published in: Biochemistry (Easton) Vol. 41; no. 40; pp. 12133 - 12139
• Main Authors: Smirnov, Ivan V, Kotch, Frank W, Pickering, Ingrid J, Davis, Jeffery T, Shafer, Richard H
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.10.2002
• Subjects: Binding Sites; Circular Dichroism; Crystallography, X-Ray; DNA - chemistry; DNA - metabolism; Guanosine - metabolism; Lead - metabolism

Nucleic acid quadruplexes are composed of guanine quartets stabilized by specific metal ions. X-ray diffraction can provide high-resolution information on the structure and metal binding properties of quadruplexes, but only if they can be crystallized. NMR can provide detailed information on the sol...