Pain chronification and chronic pain impair a defensive behavior, but not the ability of acute pain to facilitate it, through the activation of an endogenous analgesia circuit

• Published in: Behavioral neuroscience Vol. 132; no. 6; p. 614
• Main Authors: Lamana, Monaliza Simone, Miranda, Josiane, Tobaldini, Gláucia, Fischer, Luana, Tambeli, Cláudia Herrera
• Format: Journal Article
• Language: English
• Published: United States 01.12.2018
• Subjects: Acute Pain - physiopathology; Acute Pain - psychology; Animals; Capsaicin; Chronic Pain - physiopathology; Chronic Pain - psychology; Freezing Reaction, Cataleptic - physiology; Hydroxy Acids; Hyperalgesia - physiopathology; Hyperalgesia - psychology; Male; Neural Pathways - drug effects; Neural Pathways - physiopathology; Nociceptive Pain - physiopathology; Nociceptive Pain - psychology; Nucleus Accumbens - drug effects; Nucleus Accumbens - physiopathology; Oleic Acids; Pain Perception - physiology; Random Allocation; Rats, Wistar; Receptors, Opioid, mu - antagonists & inhibitors; Receptors, Opioid, mu - metabolism

The endogenous ability to decrease pain perception during life-threatening situations is crucial to the prevention of recuperative behaviors and to leave the subject free to engage in appropriated defensive responses. We have previously shown that acute pain activates the ascending nociceptive contr...