Environmental Gestagens Activate Fathead Minnow (Pimephales promelas) Nuclear Progesterone and Androgen Receptors in Vitro

• Published in: Environmental science & technology Vol. 48; no. 14; pp. 8179 - 8187
• Main Authors: Ellestad, Laura E, Cardon, Mary, Chambers, Ian G, Farmer, Jennifer L, Hartig, Phillip, Stevens, Kyle, Villeneuve, Daniel L, Wilson, Vickie, Orlando, Edward F
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 15.07.2014
• Subjects: Agnatha. Pisces; Androgens; Animal reproduction; Animal, plant and microbial ecology; Animals; Applied ecology; Biological and medical sciences; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Cyprinidae - metabolism; Ecotoxicology, biological effects of pollution; Effects of pollution and side effects of pesticides on vertebrates; Environmental Pollutants - toxicity; Female; Fish; Freshwater; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - drug effects; Male; Molecules; Organ Specificity - drug effects; Organ Specificity - genetics; Pimephales promelas; Progestins - toxicity; Receptors, Androgen - genetics; Receptors, Androgen - metabolism; Receptors, Progesterone - genetics; Receptors, Progesterone - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sequence Homology, Amino Acid; Sex Characteristics; T cell receptors; Teleostei; Vertebrates; Mimetic hormone; Androgen; Toxicity; Endocrine disruptor; In vitro; Progestagen; Vertebrata; Pisces; Environment; Pimephales promelas; Sex steroid hormone; Mechanism of action; Organic compounds; Hormonal receptor

Gestagen is a collective term for endogenous and synthetic progesterone receptor (PR) ligands. In teleost fishes, 17α,20β-dihydroxy-4-pregnen-3-one (DHP) and 17α,20β,21-trihydroxy-4-pregnen-3-one (20β-S) are the predominant progestogens, whereas in other vertebrates the major progestogen is progeste...