Synthesis of Oligoribonucleotides Containing a 2′-Amino-5′‑S‑phosphorothiolate Linkage

• Published in: Journal of organic chemistry Vol. 86; no. 19; pp. 13231 - 13244
• Main Authors: Li, Nan-Sheng, Koo, Selene C, Piccirilli, Joseph A
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.10.2021; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; PHOSPHATE; PURINE NUCLEOSIDES; NUCLEOTIDES; CATALYSIS; OLIGODEOXYNUCLEOTIDES; EVOLUTION; RNA; ANALOGS; EFFICIENT SYNTHESIS; NUCLEOPHILE

Oligoribonucleotides containing a photocaged 2′-amino-5′-S-phophorothiolate linkage have potential applications as therapeutic agents and biological probes to investigate the RNA structure and function. We envisioned that oligoribonucleotides containing a 2′-amino-5′-S-phosphorothiolate linkage coul...