Chemical Tools for K+ Channel Biology

• Published in: Biochemistry (Easton) Vol. 48; no. 3; pp. 517 - 526
• Main Authors: Ahern, Christopher A, Kobertz, William R
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.01.2009
• Subjects: Amino Acids - metabolism; Humans; Potassium Channel Blockers - pharmacology; Potassium Channels - metabolism; Protein Subunits - metabolism; Quaternary Ammonium Compounds - pharmacology; Small Molecule Libraries

K+ channels are revered for their universal action of suppressing electrical activity in nerve and muscle, as well as regulating salt and water transport in epithelial tissues involved in metabolism and digestion. These multisubunit membrane-embedded proteins carry out their physiological chore, sel...