Substrate Stiffness-Dependent Carbon Nanotube-Induced Lung Fibrogenesis

• Published in: Nano letters Vol. 19; no. 8; pp. 5443 - 5451
• Main Authors: Wang, Kai, Shi, Lin, Linthicum, Will, Man, Kun, He, Xiaoqing, Wen, Qi, Rojanasakul, Liying Wang, Rojanasakul, Yon, Yang, Yong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.08.2019
• Subjects: Cell Line; Cell Movement; Collagen Type I - analysis; Collagen Type I - metabolism; Elasticity; Fibroblasts - metabolism; Fibroblasts - pathology; Focal Adhesion Protein-Tyrosine Kinases - analysis; Focal Adhesion Protein-Tyrosine Kinases - metabolism; Humans; Lung - cytology; Lung - metabolism; Lung - pathology; Nanotubes, Carbon - adverse effects; Nanotubes, Carbon - chemistry; Pulmonary Fibrosis - etiology; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; Reactive Oxygen Species - analysis; Reactive Oxygen Species - metabolism; lung fibrogenesis; nanotoxicity; carbon nanotubes; stiffness; focal adhesion kinase; intracellular tension

Most living tissues exhibit the specific stiffness, which has been known to have profound influence on cell behaviors, yet how the stiffness affects cellular responses to engineered nanomaterials has not been elucidated. Particularly, discrepancies exist between in vitro and in vivo nanotoxicologica...