Golden Syrian Hamsters as a Model for Revisiting the Role of Biological Sex Differences in SARS-CoV-2 Infection

• Published in: mBio Vol. 12; no. 6; p. e0184821
• Main Authors: Michita, Rafael Tomoya, Mysorekar, Indira U.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 21.12.2021
• Subjects: Animals; Antibodies, Viral - blood; Commentary; COVID-19; COVID-19 - immunology; COVID-19 - physiopathology; Cricetinae; Disease Models, Animal; Female; Lung - pathology; lung infection; Male; Mesocricetus; Microbial Pathogenesis; SARS-CoV-2; SARS-CoV-2 - immunology; SARS-CoV-2 - pathogenicity; sex difference; Sex Factors; Syrian hamster; viral infections; Viral Load; COVID-19; Syrian hamster; SARS-CoV-2; viral infections; sex difference; lung infection

There is growing evidence that coronavirus disease 2019 (COVID-19) affects males more severely than females, including compelling evidence indicating that biological sex is an important clinical factor influencing disease pathology and outcomes. In their recent article in mBio , Dhakal et al. find f...