Z‑Isomers of Astaxanthin Exhibit Greater Bioavailability and Tissue Accumulation Efficiency than the All‑E‑Isomer
The purpose of the present study was to clarify the differences in the bioavailability and tissue accumulation efficiency between (all-E)- and (Z)-astaxanthin. Astaxanthin with a high proportion of the Z-isomer (especially rich in the 9Z- and 13Z-isomers) was prepared from (all-E)-astaxanthin by the...
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Published in | Journal of agricultural and food chemistry Vol. 69; no. 11; pp. 3489 - 3495 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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American Chemical Society
24.03.2021
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Abstract | The purpose of the present study was to clarify the differences in the bioavailability and tissue accumulation efficiency between (all-E)- and (Z)-astaxanthin. Astaxanthin with a high proportion of the Z-isomer (especially rich in the 9Z- and 13Z-isomers) was prepared from (all-E)-astaxanthin by thermal treatment and solid–liquid separation. The all-E-isomer- or Z-isomer-rich diet was fed to male rats for 2 weeks. After the feeding period, blood and tissue samples were collected, and their astaxanthin levels were evaluated. The Z-isomer-rich astaxanthin diet resulted in higher levels of astaxanthin in blood and many tissues (in particular, skin, lung, prostate, and eye) compared to the all-E-isomer-rich diet. Moreover, the Z-isomer-rich diet enhanced the level of the 13Z-isomer in blood and tissues rather than that of the 9Z-isomer. These results strongly supported that astaxanthin Z-isomers have greater bioavailability and tissue accumulation efficiency than the all-E-isomer. Moreover, (13Z)-astaxanthin would have higher bioavailability and tissue accumulation than the other isomers. |
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AbstractList | The purpose of the present study was to clarify the differences in the bioavailability and tissue accumulation efficiency between (all-E)- and (Z)-astaxanthin. Astaxanthin with a high proportion of the Z-isomer (especially rich in the 9Z- and 13Z-isomers) was prepared from (all-E)-astaxanthin by thermal treatment and solid–liquid separation. The all-E-isomer- or Z-isomer-rich diet was fed to male rats for 2 weeks. After the feeding period, blood and tissue samples were collected, and their astaxanthin levels were evaluated. The Z-isomer-rich astaxanthin diet resulted in higher levels of astaxanthin in blood and many tissues (in particular, skin, lung, prostate, and eye) compared to the all-E-isomer-rich diet. Moreover, the Z-isomer-rich diet enhanced the level of the 13Z-isomer in blood and tissues rather than that of the 9Z-isomer. These results strongly supported that astaxanthin Z-isomers have greater bioavailability and tissue accumulation efficiency than the all-E-isomer. Moreover, (13Z)-astaxanthin would have higher bioavailability and tissue accumulation than the other isomers. The purpose of the present study was to clarify the differences in the bioavailability and tissue accumulation efficiency between (all- )- and ( )-astaxanthin. Astaxanthin with a high proportion of the -isomer (especially rich in the 9 - and 13 -isomers) was prepared from (all- )-astaxanthin by thermal treatment and solid-liquid separation. The all- -isomer- or -isomer-rich diet was fed to male rats for 2 weeks. After the feeding period, blood and tissue samples were collected, and their astaxanthin levels were evaluated. The -isomer-rich astaxanthin diet resulted in higher levels of astaxanthin in blood and many tissues (in particular, skin, lung, prostate, and eye) compared to the all- -isomer-rich diet. Moreover, the -isomer-rich diet enhanced the level of the 13 -isomer in blood and tissues rather than that of the 9 -isomer. These results strongly supported that astaxanthin -isomers have greater bioavailability and tissue accumulation efficiency than the all- -isomer. Moreover, (13 )-astaxanthin would have higher bioavailability and tissue accumulation than the other isomers. |
Author | Honda, Masaki Osawa, Yukiko Kuroda, Ikuo Murakami, Kazuya Hirasawa, Kazuaki Kawashima, Yuki |
AuthorAffiliation | Department of Materials Process Engineering Biotechnology R&D Group Department of Chemistry, Faculty of Science & Technology Nagoya University |
AuthorAffiliation_xml | – name: Nagoya University – name: Department of Chemistry, Faculty of Science & Technology – name: Department of Materials Process Engineering – name: Biotechnology R&D Group |
Author_xml | – sequence: 1 givenname: Masaki orcidid: 0000-0001-9470-7442 surname: Honda fullname: Honda, Masaki email: honda@meijo-u.ac.jp organization: Department of Chemistry, Faculty of Science & Technology – sequence: 2 givenname: Kazuya surname: Murakami fullname: Murakami, Kazuya organization: Nagoya University – sequence: 3 givenname: Yukiko surname: Osawa fullname: Osawa, Yukiko email: osawa.yukiko@eneos.com organization: Biotechnology R&D Group – sequence: 4 givenname: Yuki surname: Kawashima fullname: Kawashima, Yuki organization: Biotechnology R&D Group – sequence: 5 givenname: Kazuaki surname: Hirasawa fullname: Hirasawa, Kazuaki organization: Biotechnology R&D Group – sequence: 6 givenname: Ikuo surname: Kuroda fullname: Kuroda, Ikuo organization: Biotechnology R&D Group |
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SubjectTerms | Animals Biological Availability Diet Food and Beverage Chemistry/Biochemistry Isomerism Male Rats Xanthophylls - metabolism |
Title | Z‑Isomers of Astaxanthin Exhibit Greater Bioavailability and Tissue Accumulation Efficiency than the All‑E‑Isomer |
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