Urolithins Are the Main Urinary Microbial-Derived Phenolic Metabolites Discriminating a Moderate Consumption of Nuts in Free-Living Subjects with Diagnosed Metabolic Syndrome

• Published in: Journal of agricultural and food chemistry Vol. 60; no. 36; pp. 8930 - 8940
• Main Authors: Tulipani, Sara, Urpi-Sarda, Mireia, Garcı́a-Villalba, Rocío, Rabassa, Montserrat, López-Uriarte, Patricia, Bulló, Mònica, Jáuregui, Olga, Tomás-Barberán, Francisco, Salas-Salvadó, Jordi, Espı́n, Juan Carlos, Andrés-Lacueva, Cristina
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Washington, DC American Chemical Society 12.09.2012
• Subjects: absorption; Adult; almonds; Bacteria - metabolism; bioavailability; Biological and medical sciences; Corylus - metabolism; Corylus avellana; Coumarins - metabolism; Coumarins - urine; diet; digestive system; excretion; Female; Food industries; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; hazelnuts; Humans; Hydrolyzable Tannins - metabolism; intestinal microorganisms; Intestines - metabolism; Intestines - microbiology; Juglans - metabolism; Juglans regia; Male; metabolic syndrome; Metabolic Syndrome - diagnosis; Metabolic Syndrome - diet therapy; Metabolic Syndrome - metabolism; Metabolic Syndrome - microbiology; metabolism; metabolites; Metagenome; Middle Aged; molecular weight; Nuts - metabolism; polyphenols; Prunus - metabolism; Prunus dulcis; risk; urine; walnuts; metabolic syndrome; microbiota; polyphenols; nuts; urolithins; hydroxyphenylvalerolactones; Consumption; Polyphenol; Nuts; Metabolite; Phenols; Microflora; Metabolism

Walnuts (Juglans regia L.), hazelnuts (Corylus avellana L.), and almonds (Prunus dulcis Mill.) are rich sources of ellagitannins and proanthocyanidins. Gut microbiota plays a crucial role in modulating the bioavailability of these high molecular weight polyphenols. However, to date there are no stud...