Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide

• Published in: Molecular pharmaceutics Vol. 12; no. 11; pp. 4166 - 4173
• Main Authors: Malm-Erjefält, Monika, Ekblom, Marianne, Vouis, Jan, Zdravkovic, Milan, Lennernäs, Hans
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.11.2015
• Subjects: Administration, Oral; Adolescent; Adult; Antifungal Agents - administration & dosage; Antifungal Agents - pharmacokinetics; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - pharmacokinetics; Atorvastatin Calcium - administration & dosage; Atorvastatin Calcium - pharmacokinetics; biopharmaceutical classification systems; Biopharmaceutics - classification; Cardiotonic Agents - administration & dosage; Cardiotonic Agents - pharmacokinetics; Computer Simulation; Cross-Over Studies; Digoxin - administration & dosage; Digoxin - pharmacokinetics; Double-Blind Method; drug interaction; Drug Interactions; Female; Gastric Emptying; Gastrointestinal Absorption; GLP-1 receptor agonist; Griseofulvin - administration & dosage; Griseofulvin - pharmacokinetics; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics; Hypoglycemic Agents - pharmacology; liraglutide; Liraglutide - pharmacology; Lisinopril - administration & dosage; Lisinopril - pharmacokinetics; Male; Middle Aged; Therapeutic Equivalency; Tissue Distribution; Young Adult; liraglutide; gastrointestinal absorption; GLP-1 receptor agonist; drug interaction; biopharmaceutical classification system

Like other GLP-1 receptor agonists used for treatment of type 2 diabetes, liraglutide delays gastric emptying. In this clinical absorption study, the primary objective was to investigate the effect of liraglutide (at steady state) on the rate and/or extent of gastrointestinal (GI) absorption of conc...