Innovations in Ventricular Assist Devices for End-Stage Heart Failure

The number of patients with end-stage heart failure (HF) continues to increase over time, but there has been little change in the availability of organs for cardiac transplantation, intensifying the demand for left ventricular assist devices (LVADs) as a bridge to transplantation. There is also a gr...

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Published inAnnual review of medicine Vol. 70; no. 1; pp. 33 - 44
Main Authors Miller, Robert J.H, Teuteberg, Jeffrey J, Hunt, Sharon A
Format Journal Article
LanguageEnglish
Published United States Annual Reviews 27.01.2019
Annual Reviews, Inc
Subjects
Adult
Aged
Congestive heart failure
Decision making
Equipment Design - methods
Equipment Design - trends
Equipment Safety
Female
Forecasting
Heart failure
Heart Failure - diagnosis
Heart Failure - mortality
Heart Failure - surgery
Heart transplantation
Heart transplants
Heart-Assist Devices - statistics & numerical data
Humans
Innovations
left ventricular assist device
LVAD
Male
mechanical circulatory support
Middle Aged
Organs
Patient Selection
Patients
Prognosis
Quality of Life
Randomized Controlled Trials as Topic
Severity of Illness Index
Survival Analysis
Technology
Transplantation
Ventricle
mechanical circulatory support
heart failure
left ventricular assist device
LVAD
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Abstract The number of patients with end-stage heart failure (HF) continues to increase over time, but there has been little change in the availability of organs for cardiac transplantation, intensifying the demand for left ventricular assist devices (LVADs) as a bridge to transplantation. There is also a growing number of patients with end-stage HF who are not transplant candidates but may be eligible for long-term support with an LVAD, known as destination therapy. Due to this increasing demand, LVAD technology has evolved, resulting in transformative improvements in outcomes. Additionally, with growing clinical experience patient management continues to be refined, leading to iterative improvements in outcomes. With outcomes continuing to improve, the potential benefit from LVAD therapy is being considered for patients earlier in their course of advanced HF. We review recent changes in technology, patient management, and implant decision making in LVAD therapy.
AbstractList The number of patients with end-stage heart failure (HF) continues to increase over time, but there has been little change in the availability of organs for cardiac transplantation, intensifying the demand for left ventricular assist devices (LVADs) as a bridge to transplantation. There is also a growing number of patients with end-stage HF who are not transplant candidates but may be eligible for long-term support with an LVAD, known as destination therapy. Due to this increasing demand, LVAD technology has evolved, resulting in transformative improvements in outcomes. Additionally, with growing clinical experience patient management continues to be refined, leading to iterative improvements in outcomes. With outcomes continuing to improve, the potential benefit from LVAD therapy is being considered for patients earlier in their course of advanced HF. We review recent changes in technology, patient management, and implant decision making in LVAD therapy.
Author Teuteberg, Jeffrey J
Hunt, Sharon A
Miller, Robert J.H
AuthorAffiliation Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, and Department of Medicine, Stanford University, Stanford, California 94305, USA; email
hunts@stanford.edu
rjhmille@stanford.edu
jeff.teuteberg@stanford.edu
,
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Keywords mechanical circulatory support
heart failure
left ventricular assist device
LVAD
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Snippet The number of patients with end-stage heart failure (HF) continues to increase over time, but there has been little change in the availability of organs for...
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SubjectTerms Adult
Aged
Congestive heart failure
Decision making
Equipment Design - methods
Equipment Design - trends
Equipment Safety
Female
Forecasting
Heart failure
Heart Failure - diagnosis
Heart Failure - mortality
Heart Failure - surgery
Heart transplantation
Heart transplants
Heart-Assist Devices - statistics & numerical data
Humans
Innovations
left ventricular assist device
LVAD
Male
mechanical circulatory support
Middle Aged
Organs
Patient Selection
Patients
Prognosis
Quality of Life
Randomized Controlled Trials as Topic
Severity of Illness Index
Survival Analysis
Technology
Transplantation
Ventricle
Title Innovations in Ventricular Assist Devices for End-Stage Heart Failure
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