Innovations in Ventricular Assist Devices for End-Stage Heart Failure

• Published in: Annual review of medicine Vol. 70; no. 1; pp. 33 - 44
• Main Authors: Miller, Robert J.H, Teuteberg, Jeffrey J, Hunt, Sharon A
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews 27.01.2019; Annual Reviews, Inc
• Subjects: Adult; Aged; Congestive heart failure; Decision making; Equipment Design - methods; Equipment Design - trends; Equipment Safety; Female; Forecasting; Heart failure; Heart Failure - diagnosis; Heart Failure - mortality; Heart Failure - surgery; Heart transplantation; Heart transplants; Heart-Assist Devices - statistics & numerical data; Humans; Innovations; left ventricular assist device; LVAD; Male; mechanical circulatory support; Middle Aged; Organs; Patient Selection; Patients; Prognosis; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Survival Analysis; Technology; Transplantation; Ventricle; mechanical circulatory support; heart failure; left ventricular assist device; LVAD
• ISSN: 0066-4219; 1545-326X
• DOI: 10.1146/annurev-med-041217-011015

The number of patients with end-stage heart failure (HF) continues to increase over time, but there has been little change in the availability of organs for cardiac transplantation, intensifying the demand for left ventricular assist devices (LVADs) as a bridge to transplantation. There is also a growing number of patients with end-stage HF who are not transplant candidates but may be eligible for long-term support with an LVAD, known as destination therapy. Due to this increasing demand, LVAD technology has evolved, resulting in transformative improvements in outcomes. Additionally, with growing clinical experience patient management continues to be refined, leading to iterative improvements in outcomes. With outcomes continuing to improve, the potential benefit from LVAD therapy is being considered for patients earlier in their course of advanced HF. We review recent changes in technology, patient management, and implant decision making in LVAD therapy.