Catalytic Asymmetric Vinylogous and Bisvinylogous Propargylic Substitution

• Published in: Journal of the American Chemical Society Vol. 144; no. 34; pp. 15779 - 15785
• Main Authors: Qian, Hao-Dong, Li, Zhi-Heng, Deng, Shuang, Yao, Chaochao, Xiang, Hua-Ming, Xu, Guang, Geng, Zi-Qi, Wang, Zihao, Chen, Linfeng, Liu, Chunrong, Zhu, Cuiju, Qi, Xiaotian, Xu, Hao
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 31.08.2022; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Multidisciplinary; enantioselective synthesis; enantioselectivity; ligands; Physical Sciences; Science & Technology; ALDOL; CYCLOADDITION; AMINATION; COPPER; ENANTIOSELECTIVE ALLYLIC SUBSTITUTION; ESTERS

Distinct regio- and enantioselectivity control in copper-catalyzed vinylogous and bisvinylogous propargylic substitution has been accomplished by using a novel chiral N,N,P ligand. The developed method provides an efficient and selective approach to an array of highly enantioenriched alkynyl unsatur...