Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal–Organic Framework

• Published in: ACS nano Vol. 13; no. 6; pp. 6879 - 6890
• Main Authors: Wang, Yuanbo, Wu, Wenbo, Liu, Jingjing, Manghnani, Purnima Naresh, Hu, Fang, Ma, Dou, Teh, Cathleen, Wang, Bo, Liu, Bin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.06.2019
• Subjects: aggregation-induced emission; photosensitizers; activatable photodynamic therapy; metal−organic frameworks; glutathione

Activation of photosensitizers (PSs) in targeted lesion and minimization of reactive oxygen species (ROS) depletion by endogenous antioxidants constitute promising approaches to perform highly effective image-guided photodynamic therapy (PDT) with minimal non-specific phototoxicity. Traditional stra...