Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization
By screening of reaction conditions and evaluation of its fluorescent properties, an environmentally sensitive fluorescent group, 8-aza-7-hydroxy-4-methylcoumarin, was synthesized in 70% yield using MgBr2 as a Lewis acid under microwave irradiation. It has a high fluorescent quantum yield, is adequa...
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| Published in | Journal of organic chemistry Vol. 82; no. 5; pp. 2739 - 2744 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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WASHINGTON
American Chemical Society
03.03.2017
Amer Chemical Soc |
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| Abstract | By screening of reaction conditions and evaluation of its fluorescent properties, an environmentally sensitive fluorescent group, 8-aza-7-hydroxy-4-methylcoumarin, was synthesized in 70% yield using MgBr2 as a Lewis acid under microwave irradiation. It has a high fluorescent quantum yield, is adequately soluble in water, and produces fluorescent emission in protic solvents and at neutral pH. Therefore, it could be useful in biosensors that are required to emit in hydrophilic environments such as cells. |
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| AbstractList | By screening of reaction conditions and evaluation of its fluorescent properties, an environmentally sensitive fluorescent group, 8-aza-7-hydroxy-4-methylcoumarin, was synthesized in. 70% yield using MgBr2 as a Lewis acid under microwave irradiation. It has a high fluorescent quantum yield, is adequately soluble in water, and produces fluorescent emission in protic solvents and at neutral pH. Therefore, it could be useful in biosensors that are required to emit in hydrophilic environments such as cells. By screening of reaction conditions and evaluation of its fluorescent properties, an environmentally sensitive fluorescent group, 8-aza-7-hydroxy-4-methylcoumarin, was synthesized in 70% yield using MgBr as a Lewis acid under microwave irradiation. It has a high fluorescent quantum yield, is adequately soluble in water, and produces fluorescent emission in protic solvents and at neutral pH. Therefore, it could be useful in biosensors that are required to emit in hydrophilic environments such as cells. |
| Author | Narumi, Tetsuo Takano, Hikaru Nomura, Wataru Tamamura, Hirokazu |
| AuthorAffiliation | Institution of Biomaterial and Bioengineering Tokyo Medical and Dental University |
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| Author_xml | – sequence: 1 givenname: Hikaru surname: Takano fullname: Takano, Hikaru – sequence: 2 givenname: Tetsuo surname: Narumi fullname: Narumi, Tetsuo – sequence: 3 givenname: Wataru surname: Nomura fullname: Nomura, Wataru – sequence: 4 givenname: Hirokazu orcidid: 0000-0003-2788-2579 surname: Tamamura fullname: Tamamura, Hirokazu email: tamamura.mr@tmd.ac.jp |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28150494$$D View this record in MEDLINE/PubMed |
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| Title | Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization |
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