The Blood Clearance Kinetics and Pathway of Polymeric Micelles in Cancer Drug Delivery

• Published in: ACS nano Vol. 12; no. 6; pp. 6179 - 6192
• Main Authors: Sun, Xuanrong, Wang, Guowei, Zhang, Hao, Hu, Shiqi, Liu, Xin, Tang, Jianbin, Shen, Youqing
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.06.2018
• Subjects: polymeric micelle; fluorescence resonance energy transfer; micelle disassembly; cancer drug delivery; micelle stability; micelle clearance pathway

Polymer micelles are one of the most investigated nanocarriers for drug delivery; many have entered clinical trials and some are in clinic use, but their delivery systems have not yet shown the expected high therapeutic efficacy in clinics. Further understanding their in vivo behaviors, particularly...