Near-Infrared-II Nanoparticles for Cancer Imaging of Immune Checkpoint Programmed Death-Ligand 1 and Photodynamic/Immune Therapy

• Published in: ACS nano Vol. 15; no. 1; pp. 515 - 525
• Main Authors: Liu, Qiang, Tian, Jiangwei, Tian, Ye, Sun, Qinchao, Sun, Dan, Wang, Feifei, Xu, Haijun, Ying, Guoliang, Wang, Jigang, Yetisen, Ali K, Jiang, Nan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.01.2021
• Subjects: Animals; B7-H1 Antigen; Cell Line, Tumor; Ligands; Mice; Nanoparticles; Photochemotherapy; NIR-II fluorophore probe; singlet oxygen quantum yield; molecular imaging; photodynamic therapy; immunotherapy

Development of second near-infrared (NIR-II) nanoparticles (NPs) with high biocompatibility, low toxicity, and high singlet oxygen quantum yield (ΦΔ) to prevent tumor recurrence is highly desirable in molecular imaging and photodynamic/immune combination therapy. Here, theranostic photosensitizer BO...