Ultrasound-Switchable Nanozyme Augments Sonodynamic Therapy against Multidrug-Resistant Bacterial Infection

• Published in: ACS nano Vol. 14; no. 2; pp. 2063 - 2076
• Main Authors: Sun, Duo, Pang, Xin, Cheng, Yi, Ming, Jiang, Xiang, Sijin, Zhang, Chang, Lv, Peng, Chu, Chengchao, Chen, Xiaolan, Liu, Gang, Zheng, Nanfeng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.02.2020
• Subjects: Animals; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Cell Survival - drug effects; Drug Resistance, Multiple, Bacterial - drug effects; Male; Methicillin-Resistant Staphylococcus aureus - drug effects; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Optical Imaging; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Palladium - chemistry; Palladium - pharmacology; Particle Size; Platinum - chemistry; Platinum - pharmacology; Porphyrins - chemistry; Porphyrins - pharmacology; Reactive Oxygen Species - metabolism; Staphylococcal Infections - drug therapy; Staphylococcal Infections - metabolism; Surface Properties; Ultrasonic Therapy; Ultrasonic Waves; sonodynamic therapy; nanozyme; bacterial infection; ultrasound-switchable; multidrug-resistant

Ultrasound (US)-driven sonodynamic therapy (SDT) has demonstrated wide application prospects in the eradication of deep-seated bacterial infections due to its noninvasiveness, site-confined irradiation, and high-tissue-penetrating capability. However, the ineffective accumulation of sonosensitizers...