Perfluorocarbon@Porphyrin Nanoparticles for Tumor Hypoxia Relief to Enhance Photodynamic Therapy against Liver Metastasis of Colon Cancer

• Published in: ACS nano Vol. 14; no. 10; pp. 13569 - 13583
• Main Authors: Liang, Xiaolong, Chen, Min, Bhattarai, Pravin, Hameed, Sadaf, Dai, Zhifei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.10.2020
• Subjects: Animals; Cell Line, Tumor; Colonic Neoplasms - drug therapy; Fluorocarbons; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - drug therapy; Mice; Nanoparticles; Oxygen; Photochemotherapy; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Porphyrins - pharmacology; Tumor Hypoxia; nanoparticle; liver metastasis; porphyrin; hypoxia relief; photodynamic therapy

Photodynamic therapy (PDT) shows great promise for the treatment of colon cancer. However, practically, it is a great challenge to use a nanocarrier for the codelivery of both the photosensitizer and oxygen to improve PDT against PDT-induced hypoxia, which is closely related to tumor metastasis. Hen...