Janus Gold Nanoplatform for Synergetic Chemoradiotherapy and Computed Tomography Imaging of Hepatocellular Carcinoma

• Published in: ACS nano Vol. 11; no. 12; pp. 12732 - 12741
• Main Authors: Wang, Zheng, Shao, Dan, Chang, Zhimin, Lu, Mengmeng, Wang, Yingshuai, Yue, Juan, Yang, Dian, Li, Mingqiang, Xu, Qiaobing, Dong, Wen-fei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.12.2017
• Subjects: Animals; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - pharmacology; Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - therapy; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemoradiotherapy; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug Screening Assays, Antitumor; Folic Acid - chemistry; Gold - chemistry; Humans; Hydrogen-Ion Concentration; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - pathology; Liver Neoplasms - therapy; Metal Nanoparticles - chemistry; Mice; Neoplasms, Experimental - diagnosis; Neoplasms, Experimental - pathology; Neoplasms, Experimental - therapy; Particle Size; Porosity; Silicon Dioxide - chemistry; Surface Properties; Tomography, X-Ray Computed; gold mesoporous silica; synergetic chemoradiotherapy; CT imaging; Janus; hepatocellular carcinoma

There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform...