Wet and Dry Processes for the Selective Transformation of Phosphonates to Phosphonic Acids Catalyzed by Brønsted Acids

• Published in: Journal of organic chemistry Vol. 85; no. 22; pp. 14411 - 14419
• Main Authors: Li, Chunya, Saga, Yuta, Onozawa, Shun-ya, Kobayashi, Shu, Sato, Kazuhiko, Fukaya, Norihisa, Han, Li-Biao
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.11.2020; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; INHIBITION; REAGENTS; ESTERS; HYDROLYSIS; DEALKYLATION; EFFICIENT; ACCESS

A “wet” process and two “dry” processes for converting phosphonate esters to phosphonic acids catalyzed by a Brønsted acid have been developed. Thus, in the presence of water, a range of alkyl-, alkenyl-, and aryl-substituted phosphonates can be generally hydrolyzed to the corresponding phosphonic a...