Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial

• Published in: JAMA : the journal of the American Medical Association Vol. 323; no. 5; pp. 423 - 431
• Main Authors: Fujii, Tomoko, Luethi, Nora, Young, Paul J, Frei, Daniel R, Eastwood, Glenn M, French, Craig J, Deane, Adam M, Shehabi, Yahya, Hajjar, Ludhmila A, Oliveira, Gisele, Udy, Andrew A, Orford, Neil, Edney, Samantha J, Hunt, Anna L, Judd, Harriet L, Bitker, Laurent, Cioccari, Luca, Naorungroj, Thummaporn, Yanase, Fumitaka, Bates, Samantha, McGain, Forbes, Hudson, Elizabeth P, Al-Bassam, Wisam, Dwivedi, Dhiraj Bhatia, Peppin, Chloe, McCracken, Phoebe, Orosz, Judit, Bailey, Michael, Bellomo, Rinaldo
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 04.02.2020
• Subjects: Administration, Intravenous; Aged; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - therapeutic use; Ascorbic acid; Ascorbic Acid - administration & dosage; Ascorbic Acid - therapeutic use; Caring for the Critically Ill Patient; Clinical trials; Drug Therapy, Combination; Female; Hospital Mortality; Hospitals; Humans; Hydrocortisone; Hydrocortisone - administration & dosage; Hydrocortisone - therapeutic use; Intensive care units; Intervention; Intravenous administration; Male; Middle Aged; Mortality; Online First; Patients; Preliminary Communication; Sepsis; Septic shock; Shock, Septic - drug therapy; Shock, Septic - mortality; Statistical analysis; Steroids; Thiamine; Thiamine - therapeutic use; Vasoconstrictor Agents - therapeutic use; Vitamin B; Vitamin C; Vitamins; Vitamins - administration & dosage; Vitamins - therapeutic use
• ISSN: 0098-7484; 1538-3598; 1538-3598
• DOI: 10.1001/jama.2019.22176

IMPORTANCE: It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock. OBJECTIVE: To determine whether the combination of vitamin C, hydrocortisone, and thiamine, compared with hydrocortisone alone, improves th...