Eudistomins A-Q, .beta.-carbolines from the antiviral Caribbean tunicate Eudistoma olivaceum

• Published in: Journal of the American Chemical Society Vol. 109; no. 11; pp. 3378 - 3387
• Main Authors: Rinehart, Kenneth L, Kobayashi, Junichi, Harbour, Gary C, Gilmore, Jeremy, Mascal, Mark, Holt, Tom G, Shield, Lois S, Lafargue, Francoise
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.05.1987; Amer Chemical Soc
• Subjects: Biological and medical sciences; Chemistry; Chemistry, Multidisciplinary; General pharmacology; Medical sciences; Pharmacology. Drug treatments; Physical Sciences; Physicochemical properties. Structure-activity relationships; Science & Technology; Marine environment; Animal origin; Antiviral; Isolation

Seventeen eudistomins have been isolated from the Caribbean colonial tunicate Eudistoma olivaceum. Twelve are .beta.-carbolines-four of them (eudistomins D, J, N, and O) unsubstituted at C-1, three (A, B, and M) with pyrrol-2-yl substituents at C-1, and five (G, H, I, P, and Q) with 1-pyrrolin-2-yl...