Biotransformation of Dimetridazole by Primary Cultures of Pig Hepatocytes

• Published in: Journal of agricultural and food chemistry Vol. 45; no. 10; pp. 3985 - 3990
• Main Authors: Hoogenboom, Laurentius A. P, Polman, Theo H. G, van Rhijn, Johannes A, Heskamp, Henry H, Foster, Brian C, Kuiper, Harry A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.10.1997
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Biological and medical sciences; CARNE; CARNE DE CERDO; DRUGS; MEAT; Medical sciences; MEDICAMENT; MEDICAMENTOS; Pharmacology. Drug treatments; PORK; RESIDU; RESIDUES; RESIDUOS; RIKILT; VIANDE; VIANDE PORCINE; Wageningen Food Safety Research; Liver; Veterinary medicine; Metabolism; In vitro; Protein; Bound form; Pig; Antiprotozoal agent; Vertebrata; Biological fixation; Mammalia; Hepatocyte; Animal; Dimetridazole; Parasiticid; Artiodactyla; Antibacterial agent; Ungulata

Monolayer cultures of pig hepatocytes were used to investigate the role of the liver in the biotransformation of the veterinary drug dimetridazole (1,2-dimethyl-5-nitroimidazole). 14C-Labeled dimetridazole (DMZ) was primarily hydroxylated to 1-methyl-2-hydroxymethyl-5-nitroimidazole (up to 90%) and...