Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells’ na...

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Published inACS applied bio materials Vol. 5; no. 9; pp. 4028 - 4054
Main Authors Anik, Muzahidul I., Mahmud, Niaz, Masud, Abdullah Al, Khan, Md Ishak, Islam, Md Nurul, Uddin, Shihab, Hossain, M. Khalid
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 19.09.2022
Subjects
age-related diseases
aging
antioxidants
reactive oxygen species
Alzheimer’s diseases
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Abstract Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells’ natural defense mechanism against ROS-mediated alteration, play an imperative role to maintain intracellular ROS homeostasis. Although the complete understanding of the ROS regulated aging process is yet to be fully comprehended, current insights into various sources of cellular ROS and their correlation with the aging process and age-related diseases are portrayed in this review. In addition, results on the effect of antioxidants on ROS homeostasis and the aging process as well as their advances in clinical trials are also discussed in detail. The future perspective in ROS-antioxidant dynamics on antiaging research is also marshaled to provide future directions for ROS-mediated antiaging research fields.
AbstractList Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells’ natural defense mechanism against ROS-mediated alteration, play an imperative role to maintain intracellular ROS homeostasis. Although the complete understanding of the ROS regulated aging process is yet to be fully comprehended, current insights into various sources of cellular ROS and their correlation with the aging process and age-related diseases are portrayed in this review. In addition, results on the effect of antioxidants on ROS homeostasis and the aging process as well as their advances in clinical trials are also discussed in detail. The future perspective in ROS-antioxidant dynamics on antiaging research is also marshaled to provide future directions for ROS-mediated antiaging research fields.
Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative role to maintain intracellular ROS homeostasis. Although the complete understanding of the ROS regulated aging process is yet to be fully comprehended, current insights into various sources of cellular ROS and their correlation with the aging process and age-related diseases are portrayed in this review. In addition, results on the effect of antioxidants on ROS homeostasis and the aging process as well as their advances in clinical trials are also discussed in detail. The future perspective in ROS-antioxidant dynamics on antiaging research is also marshaled to provide future directions for ROS-mediated antiaging research fields.Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative role to maintain intracellular ROS homeostasis. Although the complete understanding of the ROS regulated aging process is yet to be fully comprehended, current insights into various sources of cellular ROS and their correlation with the aging process and age-related diseases are portrayed in this review. In addition, results on the effect of antioxidants on ROS homeostasis and the aging process as well as their advances in clinical trials are also discussed in detail. The future perspective in ROS-antioxidant dynamics on antiaging research is also marshaled to provide future directions for ROS-mediated antiaging research fields.
Author Mahmud, Niaz
Islam, Md Nurul
Khan, Md Ishak
Uddin, Shihab
Hossain, M. Khalid
Anik, Muzahidul I.
Masud, Abdullah Al
AuthorAffiliation Massachusetts Institute of Technology
Interdisciplinary Graduate School of Engineering Science
Department of Bioregulatory Sciences, Faculty of Medicine
Department of Neurosurgery
Institute of Electronics, Atomic Energy Research Establishment
Department of Applied Chemistry, Graduate School of Engineering
Bangladesh Atomic Energy Commission
Department of Chemical Engineering
Department of Biomedical Engineering
AuthorAffiliation_xml – name: Department of Chemical Engineering
– name: Bangladesh Atomic Energy Commission
– name: Department of Bioregulatory Sciences, Faculty of Medicine
– name: Interdisciplinary Graduate School of Engineering Science
– name: Department of Neurosurgery
– name: Department of Biomedical Engineering
– name: Department of Applied Chemistry, Graduate School of Engineering
– name: Massachusetts Institute of Technology
– name: Institute of Electronics, Atomic Energy Research Establishment
Author_xml – sequence: 1
  givenname: Muzahidul I.
  orcidid: 0000-0002-5054-4175
  surname: Anik
  fullname: Anik, Muzahidul I.
  organization: Department of Chemical Engineering
– sequence: 2
  givenname: Niaz
  orcidid: 0000-0002-8244-9148
  surname: Mahmud
  fullname: Mahmud, Niaz
  organization: Department of Biomedical Engineering
– sequence: 3
  givenname: Abdullah Al
  surname: Masud
  fullname: Masud, Abdullah Al
  organization: Department of Chemical Engineering
– sequence: 4
  givenname: Md Ishak
  orcidid: 0000-0001-7680-9613
  surname: Khan
  fullname: Khan, Md Ishak
  organization: Department of Neurosurgery
– sequence: 5
  givenname: Md Nurul
  surname: Islam
  fullname: Islam, Md Nurul
  organization: Department of Bioregulatory Sciences, Faculty of Medicine
– sequence: 6
  givenname: Shihab
  orcidid: 0000-0001-5464-570X
  surname: Uddin
  fullname: Uddin, Shihab
  organization: Department of Applied Chemistry, Graduate School of Engineering
– sequence: 7
  givenname: M. Khalid
  orcidid: 0000-0003-4595-6367
  surname: Hossain
  fullname: Hossain, M. Khalid
  email: khalid.baec@gmail.com, khalid@kyudai.jp
  organization: Interdisciplinary Graduate School of Engineering Science
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36043942$$D View this record in MEDLINE/PubMed
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Snippet Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings,...
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Title Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
URI http://dx.doi.org/10.1021/acsabm.2c00411
https://www.ncbi.nlm.nih.gov/pubmed/36043942
https://www.proquest.com/docview/2708735922
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