Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain

• Published in: ACS applied bio materials Vol. 3; no. 5; pp. 3005 - 3014
• Main Authors: Higashi, Taishi, Kogo, Tetsuya, Sato, Nana, Hirotsu, Tatsunori, Misumi, Shogo, Nakamura, Hideaki, Iohara, Daisuke, Onodera, Risako, Motoyama, Keiichi, Arima, Hidetoshi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 18.05.2020
• Subjects: adamantane; pancreatic cancer; poly(ethylene glycol); cyclodextrin; bromelain

Pancreatic cancer is one of the most difficult cancers to treat largely because of the inability of anticancer drugs to penetrate into the cancer tissue as the result of the dense extracellular matrix (ECM). On the other hand, bromelain is known to degrade the ECM in cancerous tissue. However, the h...