Efficient method for the total asymmetric synthesis of the isomers of .beta.-methyltyrosine

• Published in: Journal of organic chemistry Vol. 58; no. 26; pp. 7565 - 7571
• Main Authors: Nicolas, Ernesto, Russell, K. C, Knollenberg, J, Hruby, Victor J
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.12.1993; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Exact sciences and technology; Noncondensed benzenic compounds; Organic chemistry; Physical Sciences; Preparations and properties; Science & Technology; ALPHA; DESIGN; OPTICALLY PURE ISOMERS; ANALOGS; UNUSUAL AMINO-ACIDS; METHYLPHENYLALANINE; Michael addition; α-Aminoacid; Chiral auxiliary; Asymmetric synthesis; Phenols; Benzenic compound; Methylation; Organic carbamate

Alpha-Amino acids modified at the beta-carbon atom can provide topographical constraints when incorporated into a peptide. Such modifications can modulate the physical, chemical, and biological properties of the compound. In order to properly evaluate the effect of such modifications, large-scale as...