Rational Design of Self-Assembled Cationic Porphyrin-Based Nanoparticles for Efficient Photodynamic Inactivation of Bacteria

• Published in: ACS applied materials & interfaces Vol. 12; no. 49; pp. 54378 - 54386
• Main Authors: Li, Junying, Sun, Wei, Yang, Zihuayuan, Gao, Ge, Ran, Huan-Huan, Xu, Ke-Fei, Duan, Qiu-Yi, Liu, Xiaoyang, Wu, Fu-Gen
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 09.12.2020
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Biological and Medical Applications of Materials and Interfaces; Cations - chemistry; Drug Design; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Light; Nanoparticles - chemistry; Nanoparticles - toxicity; Porphyrins - chemistry; Singlet Oxygen - metabolism; antimicrobial; porphyrin; bacterial infection; bacterial inactivation; photosensitizer

Bacterial infection has become an urgent health problem in the world. Especially, the evolving resistance of bacteria to antibiotics makes the issue more challenging, and thus new treatments to fight these infections are needed. Antibacterial photodynamic therapy (aPDT) is recognized as a novel and...