Rational Design of Self-Assembled Cationic Porphyrin-Based Nanoparticles for Efficient Photodynamic Inactivation of Bacteria
Bacterial infection has become an urgent health problem in the world. Especially, the evolving resistance of bacteria to antibiotics makes the issue more challenging, and thus new treatments to fight these infections are needed. Antibacterial photodynamic therapy (aPDT) is recognized as a novel and...
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Published in | ACS applied materials & interfaces Vol. 12; no. 49; pp. 54378 - 54386 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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American Chemical Society
09.12.2020
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Abstract | Bacterial infection has become an urgent health problem in the world. Especially, the evolving resistance of bacteria to antibiotics makes the issue more challenging, and thus new treatments to fight these infections are needed. Antibacterial photodynamic therapy (aPDT) is recognized as a novel and promising method to inactivate a wide range of bacteria with few possibilities to develop drug resistance. However, the photosensitizers (PSs) are not effective against Gram-negative bacteria in many cases. Herein, we use conjugated meso-tetra(4-carboxyphenyl)porphine (TCPP) and triaminoguanidinium chloride (TG) to construct self-assembled cationic TCPP-TG nanoparticles (NPs) for efficient bacterial inactivation under visible light illumination. The TCPP-TG NPs can rapidly adhere to both Gram-negative and Gram-positive bacteria and display promoted singlet oxygen (1O2) generation compared with TCPP under light irradiation. The high local positive charge density of TCPP-TG NPs facilitates the interaction between the NPs and bacteria. Consequently, the TCPP-TG NPs produce an elevated concentration of local 1O2 under light irradiation, resulting in an extraordinarily high antibacterial efficiency (99.9999% inactivation of the representative bacteria within 4 min). Furthermore, the TCPP-TG NPs show excellent water dispersity and stability during 4 months of storage. Therefore, the rationally designed TCPP-TG NPs are a promising antibacterial agent for effective aPDT. |
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AbstractList | Bacterial infection has become an urgent health problem in the world. Especially, the evolving resistance of bacteria to antibiotics makes the issue more challenging, and thus new treatments to fight these infections are needed. Antibacterial photodynamic therapy (aPDT) is recognized as a novel and promising method to inactivate a wide range of bacteria with few possibilities to develop drug resistance. However, the photosensitizers (PSs) are not effective against Gram-negative bacteria in many cases. Herein, we use conjugated
-tetra(4-carboxyphenyl)porphine (TCPP) and triaminoguanidinium chloride (TG) to construct self-assembled cationic TCPP-TG nanoparticles (NPs) for efficient bacterial inactivation under visible light illumination. The TCPP-TG NPs can rapidly adhere to both Gram-negative and Gram-positive bacteria and display promoted singlet oxygen (
O
) generation compared with TCPP under light irradiation. The high local positive charge density of TCPP-TG NPs facilitates the interaction between the NPs and bacteria. Consequently, the TCPP-TG NPs produce an elevated concentration of local
O
under light irradiation, resulting in an extraordinarily high antibacterial efficiency (99.9999% inactivation of the representative bacteria within 4 min). Furthermore, the TCPP-TG NPs show excellent water dispersity and stability during 4 months of storage. Therefore, the rationally designed TCPP-TG NPs are a promising antibacterial agent for effective aPDT. Bacterial infection has become an urgent health problem in the world. Especially, the evolving resistance of bacteria to antibiotics makes the issue more challenging, and thus new treatments to fight these infections are needed. Antibacterial photodynamic therapy (aPDT) is recognized as a novel and promising method to inactivate a wide range of bacteria with few possibilities to develop drug resistance. However, the photosensitizers (PSs) are not effective against Gram-negative bacteria in many cases. Herein, we use conjugated meso-tetra(4-carboxyphenyl)porphine (TCPP) and triaminoguanidinium chloride (TG) to construct self-assembled cationic TCPP-TG nanoparticles (NPs) for efficient bacterial inactivation under visible light illumination. The TCPP-TG NPs can rapidly adhere to both Gram-negative and Gram-positive bacteria and display promoted singlet oxygen (1O2) generation compared with TCPP under light irradiation. The high local positive charge density of TCPP-TG NPs facilitates the interaction between the NPs and bacteria. Consequently, the TCPP-TG NPs produce an elevated concentration of local 1O2 under light irradiation, resulting in an extraordinarily high antibacterial efficiency (99.9999% inactivation of the representative bacteria within 4 min). Furthermore, the TCPP-TG NPs show excellent water dispersity and stability during 4 months of storage. Therefore, the rationally designed TCPP-TG NPs are a promising antibacterial agent for effective aPDT. |
Author | Sun, Wei Duan, Qiu-Yi Ran, Huan-Huan Yang, Zihuayuan Wu, Fu-Gen Gao, Ge Xu, Ke-Fei Liu, Xiaoyang Li, Junying |
AuthorAffiliation | State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering |
AuthorAffiliation_xml | – name: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering |
Author_xml | – sequence: 1 givenname: Junying surname: Li fullname: Li, Junying – sequence: 2 givenname: Wei surname: Sun fullname: Sun, Wei – sequence: 3 givenname: Zihuayuan surname: Yang fullname: Yang, Zihuayuan – sequence: 4 givenname: Ge surname: Gao fullname: Gao, Ge – sequence: 5 givenname: Huan-Huan surname: Ran fullname: Ran, Huan-Huan – sequence: 6 givenname: Ke-Fei surname: Xu fullname: Xu, Ke-Fei – sequence: 7 givenname: Qiu-Yi surname: Duan fullname: Duan, Qiu-Yi – sequence: 8 givenname: Xiaoyang orcidid: 0000-0002-8649-7809 surname: Liu fullname: Liu, Xiaoyang – sequence: 9 givenname: Fu-Gen orcidid: 0000-0003-1773-2868 surname: Wu fullname: Wu, Fu-Gen email: wufg@seu.edu.cn |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33226224$$D View this record in MEDLINE/PubMed |
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Snippet | Bacterial infection has become an urgent health problem in the world. Especially, the evolving resistance of bacteria to antibiotics makes the issue more... |
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SubjectTerms | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biological and Medical Applications of Materials and Interfaces Cations - chemistry Drug Design Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Light Nanoparticles - chemistry Nanoparticles - toxicity Porphyrins - chemistry Singlet Oxygen - metabolism |
Title | Rational Design of Self-Assembled Cationic Porphyrin-Based Nanoparticles for Efficient Photodynamic Inactivation of Bacteria |
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