Biocompatible Two-Dimensional Titanium Nanosheets for Multimodal Imaging-Guided Cancer Theranostics
Photothermal therapy (PTT) based on two-dimensional (2D) nanomaterials has shown significant potential in cancer treatment. However, developing 2D nanomaterial-based theranostic agents with good biocompatibility and high therapeutic efficiency remains a key challenge. Bulk titanium (Ti) has been wid...
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Published in | ACS applied materials & interfaces Vol. 11; no. 25; pp. 22129 - 22140 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
American Chemical Society
26.06.2019
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Abstract | Photothermal therapy (PTT) based on two-dimensional (2D) nanomaterials has shown significant potential in cancer treatment. However, developing 2D nanomaterial-based theranostic agents with good biocompatibility and high therapeutic efficiency remains a key challenge. Bulk titanium (Ti) has been widely used as biomedical materials for their reputable biocompatibility, whereas nanosized Ti with a biological function remains unexplored. In this work, the 2D Ti nanosheets (NSs) are successfully exfoliated from nonlayer bulk Ti and utilized as an efficient theranostic nanoplatform for dual-modal computed tomography/photoacoustic (CT/PA) imaging-navigated PTT. Besides the excellent biocompatibility obtained by TiNSs as expected, they are found to show strong absorption ability with an extinction coefficient of 20.8 L g–1 cm–1 and high photothermal conversion ability with an efficiency of 61.5% owing to localized surface plasmon resonances, which exceeds most of other well-known photothermal agents, making it quite promising for PTT against cancer. Furthermore, the metallic property and light-heat-acoustic transformation endow 2D Ti with the strong CT/PA imaging signal and efficient cancer therapy, simultaneously. This work highlights the enormous potential of nanosized Ti in both the diagnosis and treatment of cancer. As a paradigm, this study also paves a new avenue for the elemental transition-metal-based cancer theranostics. |
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AbstractList | Photothermal therapy (PTT) based on two-dimensional (2D) nanomaterials has shown significant potential in cancer treatment. However, developing 2D nanomaterial-based theranostic agents with good biocompatibility and high therapeutic efficiency remains a key challenge. Bulk titanium (Ti) has been widely used as biomedical materials for their reputable biocompatibility, whereas nanosized Ti with a biological function remains unexplored. In this work, the 2D Ti nanosheets (NSs) are successfully exfoliated from nonlayer bulk Ti and utilized as an efficient theranostic nanoplatform for dual-modal computed tomography/photoacoustic (CT/PA) imaging-navigated PTT. Besides the excellent biocompatibility obtained by TiNSs as expected, they are found to show strong absorption ability with an extinction coefficient of 20.8 L g
cm
and high photothermal conversion ability with an efficiency of 61.5% owing to localized surface plasmon resonances, which exceeds most of other well-known photothermal agents, making it quite promising for PTT against cancer. Furthermore, the metallic property and light-heat-acoustic transformation endow 2D Ti with the strong CT/PA imaging signal and efficient cancer therapy, simultaneously. This work highlights the enormous potential of nanosized Ti in both the diagnosis and treatment of cancer. As a paradigm, this study also paves a new avenue for the elemental transition-metal-based cancer theranostics. Photothermal therapy (PTT) based on two-dimensional (2D) nanomaterials has shown significant potential in cancer treatment. However, developing 2D nanomaterial-based theranostic agents with good biocompatibility and high therapeutic efficiency remains a key challenge. Bulk titanium (Ti) has been widely used as biomedical materials for their reputable biocompatibility, whereas nanosized Ti with a biological function remains unexplored. In this work, the 2D Ti nanosheets (NSs) are successfully exfoliated from nonlayer bulk Ti and utilized as an efficient theranostic nanoplatform for dual-modal computed tomography/photoacoustic (CT/PA) imaging-navigated PTT. Besides the excellent biocompatibility obtained by TiNSs as expected, they are found to show strong absorption ability with an extinction coefficient of 20.8 L g–1 cm–1 and high photothermal conversion ability with an efficiency of 61.5% owing to localized surface plasmon resonances, which exceeds most of other well-known photothermal agents, making it quite promising for PTT against cancer. Furthermore, the metallic property and light-heat-acoustic transformation endow 2D Ti with the strong CT/PA imaging signal and efficient cancer therapy, simultaneously. This work highlights the enormous potential of nanosized Ti in both the diagnosis and treatment of cancer. As a paradigm, this study also paves a new avenue for the elemental transition-metal-based cancer theranostics. |
Author | Fan, Dianyuan Xie, Zhongjian Chen, Hong Zhang, Han Liu, Liping Lin, Zhitao Zhao, Jinlai Qu, Mengmeng Duo, Yanhong Zou, Qingshuang Fan, Taojian Zhu, Yao Li, Yang Bao, Shiyun Chen, Shiyou |
AuthorAffiliation | Macau University of Science and Technology Faculty of Information Technology Department of Hepatobiliary and Pancreatic Surgery, Shenzhen People’s Hospital School of Materials Science and Energy Engineering Guangdong Research Center for Interfacial Engineering of Functional Materials Beijing 302 Hospital SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering College of Materials Science and Engineering, Shenzhen Key Laboratory of Polymer Science and Technology Second Clinical Medical College of Jinan University Foshan University Research Center for Clinical & Translational Medicine |
AuthorAffiliation_xml | – name: Research Center for Clinical & Translational Medicine – name: Macau University of Science and Technology – name: Department of Hepatobiliary and Pancreatic Surgery, Shenzhen People’s Hospital – name: Faculty of Information Technology – name: Foshan University – name: School of Materials Science and Energy Engineering – name: Guangdong Research Center for Interfacial Engineering of Functional Materials – name: Beijing 302 Hospital – name: College of Materials Science and Engineering, Shenzhen Key Laboratory of Polymer Science and Technology – name: SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering – name: Second Clinical Medical College of Jinan University |
Author_xml | – sequence: 1 givenname: Zhongjian surname: Xie fullname: Xie, Zhongjian organization: SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering – sequence: 2 givenname: Shiyou surname: Chen fullname: Chen, Shiyou organization: SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering – sequence: 3 givenname: Yanhong surname: Duo fullname: Duo, Yanhong organization: SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering – sequence: 4 givenname: Yao surname: Zhu fullname: Zhu, Yao organization: SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering – sequence: 5 givenname: Taojian surname: Fan fullname: Fan, Taojian organization: SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering – sequence: 6 givenname: Qingshuang surname: Zou fullname: Zou, Qingshuang organization: Second Clinical Medical College of Jinan University – sequence: 7 givenname: Mengmeng surname: Qu fullname: Qu, Mengmeng organization: Beijing 302 Hospital – sequence: 8 givenname: Zhitao surname: Lin fullname: Lin, Zhitao organization: SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering – sequence: 9 givenname: Jinlai surname: Zhao fullname: Zhao, Jinlai organization: Guangdong Research Center for Interfacial Engineering of Functional Materials – sequence: 10 givenname: Yang surname: Li fullname: Li, Yang organization: Second Clinical Medical College of Jinan University – sequence: 11 givenname: Liping surname: Liu fullname: Liu, Liping email: leoliping@aliyun.com organization: Second Clinical Medical College of Jinan University – sequence: 12 givenname: Shiyun surname: Bao fullname: Bao, Shiyun organization: Second Clinical Medical College of Jinan University – sequence: 13 givenname: Hong surname: Chen fullname: Chen, Hong email: chenhongcs@126.com organization: Foshan University – sequence: 14 givenname: Dianyuan surname: Fan fullname: Fan, Dianyuan organization: Second Clinical Medical College of Jinan University – sequence: 15 givenname: Han orcidid: 0000-0002-2197-7270 surname: Zhang fullname: Zhang, Han email: hzhang@szu.edu.cn organization: SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31144494$$D View this record in MEDLINE/PubMed |
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Keywords | titanium nanosheet theranostic agent photoacoustic imaging liquid-phase exfoliation photothermal therapy |
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Snippet | Photothermal therapy (PTT) based on two-dimensional (2D) nanomaterials has shown significant potential in cancer treatment. However, developing 2D... |
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SubjectTerms | Cell Line, Tumor Cell Survival - drug effects Combined Modality Therapy Humans Multimodal Imaging - methods Nanocomposites - adverse effects Nanocomposites - chemistry Nanostructures - adverse effects Nanostructures - chemistry Photoacoustic Techniques - methods Surface Plasmon Resonance Theranostic Nanomedicine - methods Titanium - chemistry |
Title | Biocompatible Two-Dimensional Titanium Nanosheets for Multimodal Imaging-Guided Cancer Theranostics |
URI | http://dx.doi.org/10.1021/acsami.9b04628 https://www.ncbi.nlm.nih.gov/pubmed/31144494 https://search.proquest.com/docview/2232480105 |
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