Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis

• Published in: Journal of agricultural and food chemistry Vol. 66; no. 42; pp. 10964 - 10976
• Main Authors: Lin, Yen-Ning, Chang, Hsiao-Yun, Wang, Charles C. N, Chu, Fang-Yi, Shen, Hsin-Yi, Chen, Chao-Jung, Lim, Yun-Ping
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.10.2018
• Subjects: ABC transporters; agonists; AMP-activated protein kinase; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; atherosclerosis; cholesterol; fatty liver; genes; Hepatocytes - cytology; Hepatocytes - drug effects; Hepatocytes - metabolism; homeostasis; Humans; Hydrocarbons, Fluorinated - pharmacology; hyperlipidemia; intestines; leucine zipper; Ligands; lipid content; lipogenesis; Lipogenesis - drug effects; liver; Liver X Receptors - genetics; Liver X Receptors - metabolism; messenger RNA; Nuclear Receptor Coactivator 1 - genetics; Nuclear Receptor Coactivator 1 - metabolism; oleanolic acid; Oleanolic Acid - pharmacology; phosphorylation; Pregnane X Receptor - genetics; Pregnane X Receptor - metabolism; pregnanes; promoter regions; protein synthesis; steroid receptors; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Sulfonamides - pharmacology; transcriptional activation; X-radiation; reverse cholesterol transport; pregnane X receptor; lipogenesis; liver X receptor α; oleanolic acid

Liver X receptor α (LXRα) controls important biological and pathophysiological processes such as lipid homeostasis. Inhibiting LXRα transactivation may beneficial in the treatment of nonalcoholic fatty liver disease (NAFLD), which is one of the main causes of liver diseases and hyperlipidemia. Olean...