Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis - Lin, Yen-Ning; Chang, Hsiao-Yun; Wang, Charles C. N; Chu, Fang-Yi; Shen, Hsin-Yi; Chen, Chao-Jung; Lim, Yun-Ping (Journal of agricultural and food chemistry, 2018)
Keywords: ABC transporters; agonists; AMP-activated protein kinase; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; atherosclerosis; cholesterol; fatty liver; genes; Hepatocytes - cytology; Hepatocytes - drug effects; Hepatocytes - metabolism; homeostasis; Humans; Hydrocarbons, Fluorinated - pharmacology; hyperlipidemia; intestines; leucine zipper; Ligands; lipid content; lipogenesis; Lipogenesis - drug effects; liver; Liver X Receptors - genetics; Liver X Receptors - metabolism; messenger RNA; Nuclear Receptor Coactivator 1 - genetics; Nuclear Receptor Coactivator 1 - metabolism; oleanolic acid; Oleanolic Acid - pharmacology; phosphorylation; Pregnane X Receptor - genetics; Pregnane X Receptor - metabolism; pregnanes; promoter regions; protein synthesis; steroid receptors; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Sulfonamides - pharmacology; transcriptional activation; X-radiation; reverse cholesterol transport; pregnane X receptor; lipogenesis; liver X receptor α; oleanolic acid