Electrostatically Assembled Multilayered Films of Biopolymer Enhanced Nanocapsules for on-Demand Drug Release

• Published in: ACS applied bio materials Vol. 2; no. 8; pp. 3429 - 3438
• Main Authors: Xu, Li, Chu, Zihan, Wang, Hailong, Cai, Lawrence, Tu, Zhigang, Liu, Hanqing, Zhu, Chunyin, Shi, Haifeng, Pan, Donghui, Pan, Jia, Fei, Xiang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.08.2019
• Subjects: assembly; chitosan; nanoparticle; multilayer; drug delivery; fulvestrant

We describe layer-by-layer (LbL) buildup and pH-responsive behavior of multilayer films of alginate/chitosan/alginate -modified silica nanocapsules (SNCs) and chitosan (CS) biopolymers via electrostatic interaction. The SNC/CS films exhibit pH-triggered swelling/deswelling transitions under physiolo...