Butelase 1: A Versatile Ligase for Peptide and Protein Macrocyclization
Macrocyclization is a valuable tool for drug design and protein engineering. Although various methods have been developed to prepare macrocycles, a general and efficient strategy is needed. Here we report a highly efficient method using butelase 1 to macrocyclize peptides and proteins ranging in siz...
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| Published in | Journal of the American Chemical Society Vol. 137; no. 49; pp. 15398 - 15401 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
16.12.2015
Amer Chemical Soc |
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| Abstract | Macrocyclization is a valuable tool for drug design and protein engineering. Although various methods have been developed to prepare macrocycles, a general and efficient strategy is needed. Here we report a highly efficient method using butelase 1 to macrocyclize peptides and proteins ranging in sizes from 26 to >200 residues. We achieved cyclizations that are 20,000 times faster than sortase A, the most widely used ligase for protein cyclization. The reactions completed within minutes with up to 95% yields. |
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| AbstractList | Macrocyclization is a valuable tool for drug design and protein engineering. Although various methods have been developed to prepare macrocycles, a general and efficient strategy is needed. Here we report a highly efficient method using butelase 1 to macrocyclize peptides and proteins ranging in sizes from 26 to >200 residues. We achieved cyclizations that are 20,000 times faster than sortase A, the most widely used ligase for protein cyclization. The reactions completed within minutes with up to 95% yields. Macrocydization is a valuable tool for drug design and protein engineering. Although various methods have been developed to prepare macrocydes, a general and efficient strategy is needed. Here we report a highly efficient method using butelase 1 to macrocyclize peptides and proteins ranging in sizes from 26 to >200 residues. We achieved cyclizations that are 20,000 times faster than sortase A, the most widely used ligase for protein cyclization. The reactions completed within minutes with up to 95% yields. |
| Author | Tam, James P Kam, Antony Jansson, Anna E Nguyen, Giang K. T Pan, Lucy X Loo, Shining |
| AuthorAffiliation | School of Biological Sciences Nanyang Technological University |
| AuthorAffiliation_xml | – name: School of Biological Sciences – name: Nanyang Technological University |
| Author_xml | – sequence: 1 givenname: Giang K. T surname: Nguyen fullname: Nguyen, Giang K. T – sequence: 2 givenname: Antony surname: Kam fullname: Kam, Antony – sequence: 3 givenname: Shining surname: Loo fullname: Loo, Shining – sequence: 4 givenname: Anna E surname: Jansson fullname: Jansson, Anna E – sequence: 5 givenname: Lucy X surname: Pan fullname: Pan, Lucy X – sequence: 6 givenname: James P surname: Tam fullname: Tam, James P email: jptam@ntu.edu.sg |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26633100$$D View this record in MEDLINE/PubMed |
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| Snippet | Macrocyclization is a valuable tool for drug design and protein engineering. Although various methods have been developed to prepare macrocycles, a general and... Macrocydization is a valuable tool for drug design and protein engineering. Although various methods have been developed to prepare macrocydes, a general and... |
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| SubjectTerms | Amino Acid Sequence Animals Chemistry Chemistry, Multidisciplinary Cyclization drugs Humans Ligases - chemistry Ligases - metabolism Models, Molecular Molecular Sequence Data Peptide Synthases - chemistry Peptide Synthases - genetics Peptide Synthases - metabolism peptides Peptides - chemistry Peptides - metabolism Physical Sciences Plant Proteins - chemistry Plant Proteins - genetics Plant Proteins - metabolism protein engineering proteins Proteins - chemistry Proteins - metabolism Rats Science & Technology sortase A |
| Title | Butelase 1: A Versatile Ligase for Peptide and Protein Macrocyclization |
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