Hydrophobic Moiety of Cationic Lipids Strongly Modulates Their Transfection Activity

• Published in: Molecular pharmaceutics Vol. 6; no. 3; pp. 951 - 958
• Main Authors: Koynova, Rumiana, Tenchov, Boris, Wang, Li, MacDonald, Robert C
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.06.2009
• Subjects: ATOMS; BASIC BIOLOGICAL SCIENCES; CARBON; Cell Line; CHAINS; EFFICIENCY; ELECTROSTATICS; GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; GENES; Humans; HYDROCARBONS; Hydrophobic and Hydrophilic Interactions; LECITHINS; LIPIDS; MEMBRANES; Molecular Structure; NUCLEIC ACIDS; Phosphatidylcholines - chemistry; Phosphatidylethanolamines - chemistry; Structure-Activity Relationship; STRUCTURE-ACTIVITY RELATIONSHIPS; SYNTHESIS; TESTING; Transfection - methods; X-Ray Diffraction; phosphatidylethanolamine; lipoplex; transfection; Cationic phospholipid; cubic phase; hydrophobic chain; hexagonal phase
• ISSN: 1543-8384; 1543-8392
• DOI: 10.1021/mp8002573

Synthetic cationic lipids are widely used components of nonviral gene carriers, and the factors regulating their transfection efficiency are the subject of considerable interest. In view of the important role that electrostatic interactions with the polyanionic nucleic acids play in formation of lip...