Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages

• Published in: mBio Vol. 12; no. 5; p. e0198721
• Main Authors: Maemura, Tadashi, Kuroda, Makoto, Armbrust, Tammy, Yamayoshi, Seiya, Halfmann, Peter J., Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 26.10.2021
• Subjects: Immunology; Research Article; COVID-19; ADE; SARS-CoV-2; macrophages; FcγRIIIA; antibody-dependent enhancement; FcγRIIA

Viruses infect cells mainly via specific receptors at the cell surface. Antibody-dependent enhancement (ADE) of infection is an alternative mechanism of infection for viruses to infect immune cells that is mediated by antibodies and IgG receptors (FcγRs). The coronavirus disease 2019 (COVID-19) pand...