Concentrations in Plasma, Urinary Excretion, and Bactericidal Activity of Linezolid (600 Milligrams) versus Those of Ciprofloxacin (500 Milligrams) in Healthy Volunteers Receiving a Single Oral Dose

• Published in: Antimicrobial Agents and Chemotherapy Vol. 47; no. 12; pp. 3789 - 3794
• Main Authors: WAGENLEHNER, Florian M. E, WYDRA, Stephan, ONDA, Hajime, KINZIG-SCHIPPERS, Martina, SÖRGEL, Fritz, NABER, Kurt G
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.2003
• Subjects: Acetamides; Acetamides - adverse effects; Acetamides - pharmacokinetics; Acetamides - pharmacology; Adult; Anti-Infective Agents; Anti-Infective Agents - adverse effects; Anti-Infective Agents - pharmacokinetics; Anti-Infective Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Area Under Curve; Bacteria - drug effects; Biological and medical sciences; Calibration; Cephalosporins; Cephalosporins - adverse effects; Cephalosporins - pharmacokinetics; Cephalosporins - pharmacology; Ciprofloxacin; Ciprofloxacin - adverse effects; Ciprofloxacin - pharmacokinetics; Ciprofloxacin - pharmacology; Cross-Over Studies; Double-Blind Method; Enterococcus faecalis; Enterococcus faecium; Female; Half-Life; Humans; Hydrogen-Ion Concentration; Linezolid; Male; Medical sciences; Oxazolidinones; Oxazolidinones - adverse effects; Oxazolidinones - pharmacokinetics; Oxazolidinones - pharmacology; Pharmacology; Pharmacology. Drug treatments; Quality Control; Serum Bactericidal Test; Staphylococcus aureus; Staphylococcus saprophyticus; Linezolid; Urine; Biological fluid; Healthy subject; Single dose; Oral administration; Bactericidal effect; Blood plasma; Fluoroquinolone derivatives; Oxazolidinone derivative; Antibacterial agent; Ciprofloxacin; Pharmacokinetics; Oxazole derivatives; Comparative study; Quinolone derivatives

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