Asymmetric Ni-Catalyzed Radical Relayed Reductive Coupling

• Published in: Journal of the American Chemical Society Vol. 142; no. 31; pp. 13515 - 13522
• Main Authors: Wei, Xiaofeng, Shu, Wei, García-Domínguez, Andrés, Merino, Estíbaliz, Nevado, Cristina
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 05.08.2020; Amer Chemical Soc
• Subjects: alkenes; ambient temperature; amides; boranes; Chemistry; Chemistry, Multidisciplinary; cross-coupling reactions; enantioselectivity; Lewis acids; ligands; methodology; phosphonates; Physical Sciences; Science & Technology; HALIDES; DIFUNCTIONALIZATION; STYRENES; 1,2-ALKYLARYLATION; NICKEL; CARBONYL ALKYL BROMIDES; HYDROXYPHTHALIMIDE ESTERS; UNACTIVATED OLEFINS; DICARBOFUNCTIONALIZATION; TERMINAL ALKENES

Alkene dicarbofunctionalizations enable the streamlined construction of aliphatic structures and have thus been the subject of intense research efforts. Despite significant progress, catalytic asymmetric variants remain scarce. Inspired by the advantages of reductive cross-coupling approaches, we pr...