In Situ Forming, Enzyme-Responsive Peptoid-Peptide Hydrogels: An Advanced Long-Acting Injectable Drug Delivery System

• Published in: Journal of the American Chemical Society Vol. 146; no. 31; pp. 21401 - 21416
• Main Authors: Coulter, Sophie M., Pentlavalli, Sreekanth, An, Yuming, Vora, Lalitkumar K., Cross, Emily R., Moore, Jessica V., Sun, Han, Schweins, Ralf, McCarthy, Helen O., Laverty, Garry
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.08.2024
• Subjects: Animals; antiretroviral agents; blood plasma; chemical bonding; Drug Delivery Systems; hydrogels; Hydrogels - chemistry; hydrolysis; Injections, Subcutaneous; N-substituted glycines; neutrons; patients; Peptides - chemistry; Peptoids - chemistry; proteinases; Rats; Rats, Sprague-Dawley; rheology; solubilization; subcutaneous injection; Zidovudine - administration & dosage; Zidovudine - chemistry; Zidovudine - pharmacology

Long-acting drug delivery systems are promising platforms to improve patient adherence to medication by delivering drugs over sustained periods and removing the need for patients to comply with oral regimens. This research paper provides a proof-of-concept for the development of a new optimized in s...