Cu-Catalyzed Hydrocarbonylative C–C Coupling of Terminal Alkynes with Alkyl Iodides

• Published in: Journal of the American Chemical Society Vol. 139; no. 30; pp. 10200 - 10203
• Main Authors: Cheng, Li-Jie, Mankad, Neal P
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 02.08.2017; Amer Chemical Soc
• Subjects: alkynes; Chemistry; Chemistry, Multidisciplinary; electron transfer; ketones; moieties; organoiodine compounds; Physical Sciences; regioselectivity; Science & Technology; HALIDES; HYDROBORATION; MECHANISM; CARBONYLATION REACTIONS; INTERMOLECULAR HYDROACYLATION; COPPER; ALDEHYDES; DERIVATIVES; EFFICIENT METHOD; HYDROALKYLATION

A Cu-catalyzed hydrocarbonylative C–C coupling of terminal alkynes with unactivated alkyl iodides has been developed, enabling highly chemo- and regioselective synthesis of unsymmetrical dialkyl ketones. A variety of functional groups are tolerated, and both primary and secondary alkyl iodides react...