Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes

• Published in: Journal of the American Chemical Society Vol. 141; no. 18; pp. 7637 - 7643
• Main Authors: Tian, Zhi-Xiong, Qiao, Jin-Bao, Xu, Guang-Li, Pang, Xiaobo, Qi, Liangliang, Ma, Wei-Yuan, Zhao, Zhen-Zhen, Duan, Jicheng, Du, Yun-Fei, Su, Peifeng, Liu, Xue-Yuan, Shu, Xing-Zhong
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 08.05.2019; Amer Chemical Soc
• Subjects: alkenes; ambient temperature; catalytic activity; Chemistry; Chemistry, Multidisciplinary; enantioselectivity; indomethacin; Lewis acids; ligands; moieties; peptides; Physical Sciences; Science & Technology; steroids; HALIDES; DIFUNCTIONALIZATION; NICKEL; COUPLING REACTIONS; ALKYLATION; PALLADIUM-CATALYZED 1,4-DIFUNCTIONALIZATION; CONSTRUCTION; ALLYLATION; REDUCTIVE DICARBOFUNCTIONALIZATION; CYCLIZATION

Enantioselective cross-electrophile reactions remain a challenging subject in metal catalysis, and with respect to data, studies have mainly focused on stereoconvergent reactions of racemic alkyl electrophiles. Here, we report an enantioselective cross-electrophile aryl-alkenylation reaction of unac...