Elevated Heparin-Induced Antibodies Are More Common in Diabetic Patients with Vascular Disease
Background. Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft failure. The purpose of this study was to identify whether diabetes increased the likelihood of heparin-induced platelet factor 4 antibodies in at ri...
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Published in | Thrombosis Vol. 2014; no. 2014; pp. d1 - 5 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Hindawi Limiteds
01.01.2014
Hindawi Publishing Corporation John Wiley & Sons, Inc |
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Abstract | Background. Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft failure. The purpose of this study was to identify whether diabetes increased the likelihood of heparin-induced platelet factor 4 antibodies in at risk vascular patients. Methods. We reviewed clinical data on 300 consecutive patients. A hypercoagulable workup was performed if patients presented with (1) early bypass/graft thrombosis (<30 days), (2) multiple bypass/graft thrombosis, and (3) a history of DVT, pulmonary embolus (PE), or native vessel thrombosis. Relevant clinical variables were analyzed and compared between patients with diabetes (DM) and without diabetes (nDM). Results. 85 patients (47 women; age 53 ± 16 years, range 16–82 years) had one of the defined conditions and underwent a hypercoagulable evaluation. Screening was done in 4.7% of patients with early bypass graft thrombosis, 60% of patients were screened because of multiple bypass or graft thrombosis, and 35.3% had a previous history of DVT, PE, or native vessel thrombosis. Of the 43 patients with DM and 42 nDM evaluated, 59 patients (69%) had an abnormal hypercoagulable profile. An elevated heparin antibody level was present in 30% of DM and 12% of nDM patients (chi-squared test P < 0.04 ). Additionally, DM was associated with a higher likelihood of arterial complications while nDM was associated with a higher rate of venous adverse events (chi-squared test P < 0.003 ). Conclusions. Diabetes is associated with a higher likelihood of developing heparin-induced antibodies and an increased combined incidence of arterial complications that include early or multiple bypass/graft thrombosis. This finding may influence the choice of anticoagulation in diabetic patients at risk with vascular disease. |
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AbstractList | Background. Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft failure. The purpose of this study was to identify whether diabetes increased the likelihood of heparin-induced platelet factor 4 antibodies in at risk vascular patients. Methods. We reviewed clinical data on 300 consecutive patients. A hypercoagulable workup was performed if patients presented with (1) early bypass/graft thrombosis (< 30 days), (2) multiple bypass/graft thrombosis, and (3) a history of DVT, pulmonary embolus (PE), or native vessel thrombosis. Relevant clinical variables were analyzed and compared between patients with diabetes (DM) and without diabetes (nDM). Results. 85 patients (47 women; age 53 [+ or -] 16 years, range 16-82 years) had one of the defined conditions and underwent a hypercoagulable evaluation. Screening was done in 4.7% of patients with early bypass graft thrombosis, 60% of patients were screened because of multiple bypass or graft thrombosis, and 35.3% had a previous history of DVT, PE, or native vessel thrombosis. Of the 43 patients with DM and 42 nDM evaluated, 59 patients (69%) had an abnormal hypercoagulable profile. An elevated heparin antibody level was present in 30% of DM and 12% of nDM patients (chi-squared test P < 0.04). Additionally, DM was associated with a higher likelihood of arterial complications while nDM was associated with a higher rate of venous adverse events (chi-squared test P < 0.003). Conclusions. Diabetes is associated with a higher likelihood of developing heparin-induced antibodies and an increased combined incidence of arterial complications that include early or multiple bypass/graft thrombosis. This finding may influence the choice of anticoagulation in diabetic patients at risk with vascular disease. Background. Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft failure. The purpose of this study was to identify whether diabetes increased the likelihood of heparin-induced platelet factor 4 antibodies in at risk vascular patients. Methods. We reviewed clinical data on 300 consecutive patients. A hypercoagulable workup was performed if patients presented with (1) early bypass/graft thrombosis (<30 days), (2) multiple bypass/graft thrombosis, and (3) a history of DVT, pulmonary embolus (PE), or native vessel thrombosis. Relevant clinical variables were analyzed and compared between patients with diabetes (DM) and without diabetes (nDM). Results. 85 patients (47 women; age 53 ± 16 years, range 16–82 years) had one of the defined conditions and underwent a hypercoagulable evaluation. Screening was done in 4.7% of patients with early bypass graft thrombosis, 60% of patients were screened because of multiple bypass or graft thrombosis, and 35.3% had a previous history of DVT, PE, or native vessel thrombosis. Of the 43 patients with DM and 42 nDM evaluated, 59 patients (69%) had an abnormal hypercoagulable profile. An elevated heparin antibody level was present in 30% of DM and 12% of nDM patients (chi-squared test P < 0.04 ). Additionally, DM was associated with a higher likelihood of arterial complications while nDM was associated with a higher rate of venous adverse events (chi-squared test P < 0.003 ). Conclusions. Diabetes is associated with a higher likelihood of developing heparin-induced antibodies and an increased combined incidence of arterial complications that include early or multiple bypass/graft thrombosis. This finding may influence the choice of anticoagulation in diabetic patients at risk with vascular disease. Background . Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft failure. The purpose of this study was to identify whether diabetes increased the likelihood of heparin-induced platelet factor 4 antibodies in at risk vascular patients. Methods . We reviewed clinical data on 300 consecutive patients. A hypercoagulable workup was performed if patients presented with (1) early bypass/graft thrombosis (<30 days), (2) multiple bypass/graft thrombosis, and (3) a history of DVT, pulmonary embolus (PE), or native vessel thrombosis. Relevant clinical variables were analyzed and compared between patients with diabetes (DM) and without diabetes (nDM). Results . 85 patients (47 women; age 53 ± 16 years, range 16–82 years) had one of the defined conditions and underwent a hypercoagulable evaluation. Screening was done in 4.7% of patients with early bypass graft thrombosis, 60% of patients were screened because of multiple bypass or graft thrombosis, and 35.3% had a previous history of DVT, PE, or native vessel thrombosis. Of the 43 patients with DM and 42 nDM evaluated, 59 patients (69%) had an abnormal hypercoagulable profile. An elevated heparin antibody level was present in 30% of DM and 12% of nDM patients (chi-squared test P < 0.04 ). Additionally, DM was associated with a higher likelihood of arterial complications while nDM was associated with a higher rate of venous adverse events (chi-squared test P < 0.003 ). Conclusions . Diabetes is associated with a higher likelihood of developing heparin-induced antibodies and an increased combined incidence of arterial complications that include early or multiple bypass/graft thrombosis. This finding may influence the choice of anticoagulation in diabetic patients at risk with vascular disease. Background . Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft failure. The purpose of this study was to identify whether diabetes increased the likelihood of heparin-induced platelet factor 4 antibodies in at risk vascular patients. Methods . We reviewed clinical data on 300 consecutive patients. A hypercoagulable workup was performed if patients presented with (1) early bypass/graft thrombosis (<30 days), (2) multiple bypass/graft thrombosis, and (3) a history of DVT, pulmonary embolus (PE), or native vessel thrombosis. Relevant clinical variables were analyzed and compared between patients with diabetes (DM) and without diabetes (nDM). Results . 85 patients (47 women; age 53 ± 16 years, range 16–82 years) had one of the defined conditions and underwent a hypercoagulable evaluation. Screening was done in 4.7% of patients with early bypass graft thrombosis, 60% of patients were screened because of multiple bypass or graft thrombosis, and 35.3% had a previous history of DVT, PE, or native vessel thrombosis. Of the 43 patients with DM and 42 nDM evaluated, 59 patients (69%) had an abnormal hypercoagulable profile. An elevated heparin antibody level was present in 30% of DM and 12% of nDM patients (chi-squared test P < 0.04). Additionally, DM was associated with a higher likelihood of arterial complications while nDM was associated with a higher rate of venous adverse events (chi-squared test P < 0.003). Conclusions . Diabetes is associated with a higher likelihood of developing heparin-induced antibodies and an increased combined incidence of arterial complications that include early or multiple bypass/graft thrombosis. This finding may influence the choice of anticoagulation in diabetic patients at risk with vascular disease. |
Audience | Academic |
Author | Nibal R. Chamoun Eric K. Peden Mitul S. Patel Jean Bismuth Tiffany K. Street HosamF. El-Sayed Joseph J. Naoum Mazen Haydar Alan B. Lumsden Mark G. Davies |
AuthorAffiliation | 2 Houston Methodist and DeBakey Heart and Vascular Center, Houston, TX, USA 1 Lebanese American University and University Medical Center Rizk Hospital, P.O. Box 11-3288, Zahar Street, Achrafieh, Beirut, Lebanon |
AuthorAffiliation_xml | – name: 1 Lebanese American University and University Medical Center Rizk Hospital, P.O. Box 11-3288, Zahar Street, Achrafieh, Beirut, Lebanon – name: 2 Houston Methodist and DeBakey Heart and Vascular Center, Houston, TX, USA |
Author_xml | – sequence: 1 givenname: Joseph J. surname: Naoum fullname: Naoum, Joseph J. organization: Lebanese American University and University Medical Center Rizk Hospital P.O. Box 11-3288 Zahar Street, Achrafieh Beirut Lebanon lau.edu.lb – sequence: 2 givenname: Nibal R. surname: Chamoun fullname: Chamoun, Nibal R. organization: Lebanese American University and University Medical Center Rizk Hospital P.O. Box 11-3288 Zahar Street, Achrafieh Beirut Lebanon lau.edu.lb – sequence: 3 givenname: Mitul S. surname: Patel fullname: Patel, Mitul S. organization: Houston Methodist and DeBakey Heart and Vascular Center Houston, TX USA – sequence: 4 givenname: Tiffany K. surname: Street fullname: Street, Tiffany K. organization: Houston Methodist and DeBakey Heart and Vascular Center Houston, TX USA – sequence: 5 givenname: Mazen surname: Haydar fullname: Haydar, Mazen organization: Lebanese American University and University Medical Center Rizk Hospital P.O. Box 11-3288 Zahar Street, Achrafieh Beirut Lebanon lau.edu.lb – sequence: 6 givenname: Jean surname: Bismuth fullname: Bismuth, Jean organization: Houston Methodist and DeBakey Heart and Vascular Center Houston, TX USA – sequence: 7 givenname: Hosam F. surname: El-Sayed fullname: El-Sayed, Hosam F. organization: Houston Methodist and DeBakey Heart and Vascular Center Houston, TX USA – sequence: 8 givenname: Mark G. surname: Davies fullname: Davies, Mark G. organization: Houston Methodist and DeBakey Heart and Vascular Center Houston, TX USA – sequence: 9 givenname: Alan B. surname: Lumsden fullname: Lumsden, Alan B. organization: Houston Methodist and DeBakey Heart and Vascular Center Houston, TX USA – sequence: 10 givenname: Eric K. surname: Peden fullname: Peden, Eric K. organization: Houston Methodist and DeBakey Heart and Vascular Center Houston, TX USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24672719$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1177_1076029618808915 crossref_primary_10_1177_20503121241247471 crossref_primary_10_1007_s11255_018_2002_y crossref_primary_10_1155_2017_9876819 |
Cites_doi | 10.1136/hrt.2008.160549 10.2106/JBJS.L.00109 10.1016/j.jtcvs.2005.07.052 10.1159/000206901 10.1016/j.athoracsur.2006.12.011 10.1007/s11239-011-0569-6 10.2174/1566524053766059 10.1007/s11239-008-0217-y 10.1002/jemt.10092 10.1093/ndtplus/sfq056 10.1371/journal.pone.0062239 10.1111/j.1445-5994.1989.tb00220.x 10.1161/ATVBAHA.109.189290 10.1159/000049027 10.1016/j.arth.2012.07.023 10.1016/j.amjmed.2011.12.004 10.1378/chest.127.2_suppl.9S 10.1016/j.ahj.2007.03.013 10.1007/s11239-012-0785-8 10.1213/00000539-200102000-00012 10.1186/1477-9560-11-7 10.2215/CJN.01170209 10.1345/aph.1P709 10.1093/intimm/14.2.121 10.1097/MBC.0b013e3283436401 10.1177/1076029609350621 10.1016/S1056-8727(00)00132-X 10.1378/chest.11-2303 10.1159/000068427 |
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Copyright | Copyright © 2014 Joseph J. Naoum et al. COPYRIGHT 2014 John Wiley & Sons, Inc. Copyright © 2014 Joseph J. Naoum et al. 2014 |
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References | (16) 2013; 8 (5) 2001; 15 (2) 2006; 113 (14) 2009; 95 (4) 1989; 19 (21) 2002; 57 (19) 2013; 11 (7) 2002; 14 (15) 2010; 5 (31) 2012; 141 (32) 2012; 34 (13) 2007; 153 (24) 2013; 95 (30) 2011; 45 (11) 2008; 26 (17) 1984; 37 (26) 2012; 125 (29) 2001; 92 (6) 2005; 127 (22) 2001; 9 (1) 2003; 70 (33) 2011; 31 (25) 2013; 28 (8) 2010; 16 (10) 2005; 130 (9) 2010; 3 (18) 1988; 29 (3) 1983; 69 (12) 2000; 1 (20) 2005; 5 (27) 2009; 29 (23) 2011; 22 (28) 2007; 83 12584387 - Respiration. 2003 Jan-Feb;70(1):7-30 11259926 - J Diabetes Complications. 2001 Jan-Feb;15(1):44-54 16549646 - Circulation. 2006 Mar 21;113(11):e463-654 15892651 - Curr Mol Med. 2005 May;5(3):323-32 22315270 - Chest. 2012 Feb;141(2 Suppl):e495S-530S 23446446 - J Bone Joint Surg Am. 2013 Mar 20;95(6):481-7 23153599 - J Arthroplasty. 2013 Apr;28(4):595-7 11847482 - Neuroimmunomodulation. 2001;9(4):203-8 18369708 - J Thromb Thrombolysis. 2008 Aug;26(1):55-61 21327506 - J Thromb Thrombolysis. 2011 Apr;31(3):353-66 10868921 - Ital Heart J. 2000 Jan;1(1):39-42 21386022 - Ann Pharmacother. 2011 Mar;45(3):e16 11809731 - Int Immunol. 2002 Feb;14(2):121-9 17540189 - Am Heart J. 2007 Jun;153(6):900-6 12112445 - Microsc Res Tech. 2002 Jun 1;57(5):390-407 23646121 - PLoS One. 2013 Apr 30;8(4):e62239 25949440 - NDT Plus. 2010 Aug;3(4):393-6 6219531 - Acta Haematol. 1983;69(4):254-9 22560173 - Am J Med. 2012 Jul;125(7):709-16 6202721 - J Clin Pathol. 1984 Jun;37(6):659-64 15706026 - Chest. 2005 Feb;127(2 Suppl):9S-20S 19482851 - Heart. 2009 Aug;95(16):1350-4 11159229 - Anesth Analg. 2001 Feb;92 (2):344-6 2967258 - Invest Ophthalmol Vis Sci. 1988 Jun;29(6):856-60 22843169 - J Thromb Thrombolysis. 2012 Nov;34(4):552-61 20299390 - Clin Appl Thromb Hemost. 2010 Apr;16(2):121-5 2504137 - Aust N Z J Med. 1989 Apr;19(2):126-31 20185595 - Clin J Am Soc Nephrol. 2010 May;5(5):874-81 17462391 - Ann Thorac Surg. 2007 May;83(5):1737-43 23561460 - Thromb J. 2013 Apr 05;11(1):7 21346557 - Blood Coagul Fibrinolysis. 2011 Apr;22(3):155-9 16308000 - J Thorac Cardiovasc Surg. 2005 Dec;130(6):1567-72 19542020 - Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1399-405 22 23 26 27 28 30 31 10 11 33 13 14 15 17 1 5 6 8 9 20 21 |
References_xml | – volume: 16 start-page: 121 issue: 2 year: 2010 end-page: 125 ident: 8 article-title: Profiling of heparin-induced thrombocytopenia antibody levels in patients with and without diabetes publication-title: – volume: 69 start-page: 254 issue: 4 year: 1983 end-page: 259 ident: 3 article-title: Diabetes, a hypercoagulable state? Haemostatic variables in newly diagnosed type 2 diabetic patients publication-title: – volume: 34 start-page: 552 issue: 4 year: 2012 end-page: 561 ident: 32 article-title: Antithrombotic therapy in heparin induced thrombocytopenia: guidelines translated for the clinician publication-title: – volume: 19 start-page: 126 issue: 2 year: 1989 end-page: 131 ident: 4 article-title: Platelet aggregating activity in the plasma of patients with established thrombosis publication-title: – volume: 141 start-page: e495 issue: 2 year: 2012 end-page: e530 ident: 31 article-title: Treatment and prevention of heparin-induced thrombocytopenia: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines publication-title: – volume: 8 issue: 4 year: 2013 ident: 16 article-title: The clinical significance and risk factors of anti-platelet factor 4/heparin antibody on maintenance hemodialysis patients: a two-year prospective follow-up publication-title: – volume: 29 start-page: 856 issue: 6 year: 1988 end-page: 860 ident: 18 article-title: Plasma fibrinopeptide A, -thromboglobulin, and platelet factor 4 in diabetic retinopathy publication-title: – volume: 3 start-page: 393 issue: 4 year: 2010 end-page: 396 ident: 9 article-title: Hereditary and acquired thrombophilic disorders complicating vascular access in haemodialysis publication-title: – volume: 95 start-page: 481 issue: 6 year: 2013 end-page: 487 ident: 24 article-title: Surgical outcomes of total knee replacement according to diabetes status and glycemic control, 2001 to 2009 publication-title: – volume: 31 start-page: 353 issue: 3 year: 2011 end-page: 366 ident: 33 article-title: Heparin-induced thrombocytopenia: present and future publication-title: – volume: 83 start-page: 1737 issue: 5 year: 2007 end-page: 1743 ident: 28 article-title: Positive heparin-platelet factor 4 antibody complex and cardiac surgical outcomes publication-title: – volume: 9 start-page: 203 issue: 4 year: 2001 end-page: 208 ident: 22 article-title: Influence of reduced nicotinamide adenine dinucleotide on the production of interleukin-6 by peripheral human blood leukocytes publication-title: – volume: 127 issue: 2 year: 2005 ident: 6 article-title: The pathophysiology of heparin-induced thrombocytopenia: biological basis for treatment publication-title: – volume: 92 start-page: 344 issue: 2 year: 2001 end-page: 346 ident: 29 article-title: The use of lepirudin for anticoagulation in patients with heparin-induced thrombocytopenia during major vascular surgery publication-title: – volume: 153 start-page: 900 issue: 6 year: 2007 end-page: 906 ident: 13 article-title: Beyond the platelet count: heparin antibodies as independent risk predictors publication-title: – volume: 130 start-page: 1567 issue: 6 year: 2005 end-page: 1572 ident: 10 article-title: Preoperative anti-PF4/heparin antibody level predicts adverse outcome after cardiac surgery publication-title: – volume: 5 start-page: 323 issue: 3 year: 2005 end-page: 332 ident: 20 article-title: Type 2 diabetes: an atherothrombotic syndrome publication-title: – volume: 29 start-page: 1399 issue: 9 year: 2009 end-page: 1405 ident: 27 article-title: Is diabetes mellitus an independent risk factor for venous thromboembolism? a population-based case-control study publication-title: – volume: 11 start-page: 7 issue: 1 year: 2013 ident: 19 article-title: Emphasis on the role of PF4 in the incidence, pathophysiology and treatment of heparin induced thrombocytopenia publication-title: – volume: 26 start-page: 55 issue: 1 year: 2008 end-page: 61 ident: 11 article-title: Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results publication-title: – volume: 70 start-page: 7 issue: 1 year: 2003 end-page: 30 ident: 1 article-title: Principle mechanisms underlying venous thromboembolism: epidemiology, risk factors, pathophysiology and pathogenesis publication-title: – volume: 45 start-page: e16 issue: 3 year: 2011 ident: 30 article-title: Use of argatroban as a procedural and bridging anticoagulant in a patient undergoing carotid endarterectomy with concomitant atrial fibrillation publication-title: – volume: 5 start-page: 874 issue: 5 year: 2010 end-page: 881 ident: 15 article-title: Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes publication-title: – volume: 22 start-page: 155 issue: 3 year: 2011 end-page: 159 ident: 23 article-title: Some considerations about the hypercoagulable states and their treatments publication-title: – volume: 14 start-page: 121 issue: 2 year: 2002 end-page: 129 ident: 7 article-title: Anti-platelet factor 4/heparin antibodies from patients with heparin-induced thrombocytopenia provoke direct activation of microvascular endothelial cells publication-title: – volume: 95 start-page: 1350 issue: 16 year: 2009 end-page: 1354 ident: 14 article-title: Thrombotic events in patients with antiplatelet factor 4/heparin antibodies publication-title: – volume: 37 start-page: 659 issue: 6 year: 1984 end-page: 664 ident: 17 article-title: Platelet and coagulation factors in proliferative diabetic retinopathy publication-title: – volume: 15 start-page: 44 issue: 1 year: 2001 end-page: 54 ident: 5 article-title: Diabetes mellitus: a hypercoagulable state publication-title: – volume: 28 start-page: 595 issue: 4 year: 2013 end-page: 597 ident: 25 article-title: Diabetes mellitus and the incidence of deep vein thrombosis after total knee arthroplasty: a retrospective study publication-title: – volume: 1 start-page: 39 issue: 1 year: 2000 end-page: 42 ident: 12 article-title: Heparin-induced thrombocytopenia in patients treated with unfractionated heparin: prevalence of thrombosis in a 1 year follow-up publication-title: – volume: 113 start-page: e463 issue: 11 year: 2006 end-page: e654 ident: 2 article-title: ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation publication-title: – volume: 125 start-page: 709 issue: 7 year: 2012 end-page: 716 ident: 26 article-title: Venous thromboembolism in patients with diabetes mellitus publication-title: – volume: 57 start-page: 390 issue: 5 year: 2002 end-page: 407 ident: 21 article-title: Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF publication-title: – volume: 113 start-page: e463 issue: 11 year: 2006 ident: 2 publication-title: Circulation – ident: 14 doi: 10.1136/hrt.2008.160549 – volume: 95 start-page: 481 issue: 6 year: 2013 ident: 24 publication-title: Journal of Bone and Joint Surgery. American doi: 10.2106/JBJS.L.00109 – ident: 10 doi: 10.1016/j.jtcvs.2005.07.052 – volume: 69 start-page: 254 issue: 4 year: 1983 ident: 3 publication-title: Acta Haematologica doi: 10.1159/000206901 – ident: 28 doi: 10.1016/j.athoracsur.2006.12.011 – ident: 33 doi: 10.1007/s11239-011-0569-6 – ident: 20 doi: 10.2174/1566524053766059 – ident: 11 doi: 10.1007/s11239-008-0217-y – ident: 21 doi: 10.1002/jemt.10092 – ident: 9 doi: 10.1093/ndtplus/sfq056 – volume: 1 start-page: 39 issue: 1 year: 2000 ident: 12 publication-title: Italian Heart Journal – volume: 29 start-page: 856 issue: 6 year: 1988 ident: 18 publication-title: Investigative Ophthalmology and Visual Science – ident: 17 doi: 10.1371/journal.pone.0062239 – volume: 19 start-page: 126 issue: 2 year: 1989 ident: 4 publication-title: Australian and New Zealand Journal of Medicine doi: 10.1111/j.1445-5994.1989.tb00220.x – ident: 27 doi: 10.1161/ATVBAHA.109.189290 – ident: 22 doi: 10.1159/000049027 – volume: 28 start-page: 595 issue: 4 year: 2013 ident: 25 publication-title: The Journal of Arthroplasty doi: 10.1016/j.arth.2012.07.023 – ident: 26 doi: 10.1016/j.amjmed.2011.12.004 – ident: 6 doi: 10.1378/chest.127.2_suppl.9S – ident: 13 doi: 10.1016/j.ahj.2007.03.013 – volume: 34 start-page: 552 issue: 4 year: 2012 ident: 32 publication-title: Journal of Thrombosis and Thrombolysis doi: 10.1007/s11239-012-0785-8 – volume: 92 start-page: 344 issue: 2 year: 2001 ident: 29 publication-title: Anesthesia and Analgesia doi: 10.1213/00000539-200102000-00012 – volume: 11 start-page: 7 issue: 1 year: 2013 ident: 19 publication-title: Thrombosis Journal doi: 10.1186/1477-9560-11-7 – ident: 15 doi: 10.2215/CJN.01170209 – ident: 30 doi: 10.1345/aph.1P709 – volume: 14 start-page: 121 issue: 2 year: 2002 ident: 7 publication-title: International Immunology doi: 10.1093/intimm/14.2.121 – ident: 23 doi: 10.1097/MBC.0b013e3283436401 – ident: 8 doi: 10.1177/1076029609350621 – volume: 8 issue: 4 year: 2013 ident: 16 publication-title: PLoS ONE – ident: 5 doi: 10.1016/S1056-8727(00)00132-X – ident: 31 doi: 10.1378/chest.11-2303 – ident: 1 doi: 10.1159/000068427 |
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Snippet | Background. Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft failure.... Background . Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft... |
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Title | Elevated Heparin-Induced Antibodies Are More Common in Diabetic Patients with Vascular Disease |
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