Sequence and Stacking Dependence of 8-Oxoguanine Oxidation:  Comparison of One-Electron vs Singlet Oxygen Mechanisms

The oxidation of 7,8-dihydro-8-oxoguanine (8-oxoG)-containing oligodeoxynucleotides has been investigated using a variety of oxidants, including one-electron oxidants (Ir(IV), Fe(III), NiCR/KHSO5, and SO4 -•) as well as singlet oxygen, generated both photochemically and thermally. The extents of oxi...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 121; no. 40; pp. 9423 - 9428
Main Authors Hickerson, Robyn P, Prat, Ferran, Muller, James G, Foote, Christopher S, Burrows, Cynthia J
Format Journal Article
LanguageEnglish
Published American Chemical Society 13.10.1999
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