Biomimetic Nanoparticles Enhance Recovery of Movement Disorders in Parkinson’s Disease by Improving Microglial Mitochondrial Homeostasis and Suppressing Neuroinflammation - Li, Liang; Sun, Chunbin; Cai, Shanglin; Hang, Zhongci; Gao, Xiaoyu; Hou, Liangxuan; Li, Luping; Wu, Yawen; Xing, Cencan; Du, Hongwu (ACS applied materials & interfaces, 2025)
Keywords: Animals; autophagy; bioavailability; Biological and Medical Applications of Materials and Interfaces; Biomimetic Materials - chemistry; Biomimetic Materials - pharmacology; biomimetics; brain; cognitive disorders; Disease Models, Animal; Dopaminergic Neurons - drug effects; fluorescent antibody technique; homeostasis; Homeostasis - drug effects; Humans; inflammation; Inflammation - drug therapy; Male; membrane potential; metformin; Metformin - chemistry; Metformin - pharmacology; Metformin - therapeutic use; Mice; Mice, Inbred C57BL; Microglia - drug effects; Microglia - metabolism; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; mitochondrial membrane; nanoparticles; Nanoparticles - chemistry; neuroglia; Neuroinflammatory Diseases - drug therapy; oxidative stress; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Parkinson Disease - pathology; risk factors; therapeutics; transcriptomics; neuroinflammation; microglia; mitochondrial homeostasis; Parkinson’s disease; bionic nanoparticles