2‑(Pyridin-2-yl)isopropyl (PIP) Amine: An Enabling Directing Group for Divergent and Asymmetric Functionalization of Unactivated Methylene C(sp3)–H Bonds

• Published in: Accounts of chemical research Vol. 54; no. 12; pp. 2750 - 2763
• Main Authors: Zhang, Qi, Shi, Bing-Feng
• Format: Journal Article
• Language: English
• Published: American Chemical Society 15.06.2021

Conspectus Directing group (DG) assistance provides a good solution to the problems of reactivity and selectivity, two of the fundamental challenges in C­(sp3)–H activation. However, the activation of unbiased methylene C­(sp3)–H bonds remains challenging due to the high heterolytic bond dissociatio...