Spatiotemporally Targeted Nanomedicine Overcomes Hypoxia-Induced Drug Resistance of Tumor Cells after Disrupting Neovasculature

• Published in: Nano letters Vol. 20; no. 8; pp. 6191 - 6198
• Main Authors: Chen, Jinjin, Jiang, Zhongyu, Xu, Weiguo, Sun, Tianmeng, Zhuang, Xiuli, Ding, Jianxun, Chen, Xuesi
• Format: Journal Article
• Language: English
• Published: American Chemical Society 12.08.2020
• Subjects: spatiotemporally targeted drug delivery; vascular disrupting agent; shell-stacked nanoparticle; combination cancer therapy; cytostatic drug

Vascular disrupting agents (VDAs) are emerging anticancer agents, which show rising demand for combination with cytostatic drugs (CSDs), owing to inadequate tumor inhibition when applied singly. Nevertheless, the combination remains a challenge due to the different working sites of VDAs and CSDs and...