Heat Stroke in Cell Tissues Related to Sulfur Dioxide Level Is Precisely Monitored by Light-Controlled Fluorescent Probes
Heat stroke (HS) can cause serious organism damage or even death. Early understanding of the mechanism of heat cytotoxicity can prevent or treat heat stroke related diseases. In this work, probe Ly-NT-SP was synthesized, characterized, and used for sulfur dioxide (SO2) detection in lysosomes. PBS so...
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| Published in | Journal of the American Chemical Society Vol. 142; no. 6; pp. 3262 - 3268 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
12.02.2020
Amer Chemical Soc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Heat stroke (HS) can cause serious organism damage or even death. Early understanding of the mechanism of heat cytotoxicity can prevent or treat heat stroke related diseases. In this work, probe Ly-NT-SP was synthesized, characterized, and used for sulfur dioxide (SO2) detection in lysosomes. PBS solutions of probe Ly-NT-SP at pH 5.0 present a marked broad emission band in the green zone (535 nm). After UV irradiation, the spiropyran group in Ly-NT-SP isomerizes to the merocyanine form (Ly-NT-MR), which presented a weak red-shifted emission at 630 nm. In addition, photocontrolled isomerization of Ly-NT-SP to Ly-NT-MR generated a CC–CN+ fragment able to react, through a Michael addition, with SO2 to yield a highly emissive adduct with a marked fluorescence in the green channel (535 nm). In vitro studies showed a remarkable selectivity of photoactivated Ly-NT-MR to SO2 with a limit of detection as low as 4.7 μM. MTT viability assays demonstrated that the Ly-NT-SP is nontoxic to HeLa cells and can be used to detect SO2 in lysosomes. Taking advantage of this, the sensor is successfully applied to image increasing SO2 values in lysosomes during heat shock for the first time. Moreover, we also confirmed that the increased SO2 can protect the small intestine against damage induced by heat shock through regulating oxidative stress in cells and mice. |
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| AbstractList | ( )Heat stroke (HS) can cause serious organism damage or even death. Early understanding of the mechanism of heat cytotoxicity can prevent or treat heat stroke related diseases. In this work, probe Ly-NT-SP was synthesized, characterized, and used for sulfur dioxide (SO2) detection in lysosomes. PBS solutions of probe Ly-NT-SP at pH 5.0 present a marked broad emission band in the green zone (535 nm). After UV irradiation, the spiropyran group in Ly-NT-SP isomerizes to the merocyanine form (Ly-NT-MR), which presented a weak red-shifted emission at 630 nm. In addition, photocontrolled isomerization of Ly-NT-SP to Ly-NT-MR generated a C=C-C=N+ fragment able to react, through a Michael addition, with SO2 to yield a highly emissive adduct with a marked fluorescence in the green channel (535 nm). In vitro studies showed a remarkable selectivity of photoactivated Ly-NT-MR to SO2 with a limit of detection as low as 4.7 mu M. MTT viability assays demonstrated that the Ly-NT-SP is nontoxic to HeLa cells and can be used to detect SO2 in lysosomes. Taking advantage of this, the sensor is successfully applied to image increasing SO2 values in lysosomes during heat shock for the first time. Moreover, we also confirmed that the increased SO2 can protect the small intestine against damage induced by heat shock through regulating oxidative stress in cells and mice. Heat stroke (HS) can cause serious organism damage or even death. Early understanding of the mechanism of heat cytotoxicity can prevent or treat heat stroke related diseases. In this work, probe was synthesized, characterized, and used for sulfur dioxide (SO ) detection in lysosomes. PBS solutions of probe at pH 5.0 present a marked broad emission band in the green zone (535 nm). After UV irradiation, the spiropyran group in isomerizes to the merocyanine form ( ), which presented a weak red-shifted emission at 630 nm. In addition, photocontrolled isomerization of to generated a C═C-C═N fragment able to react, through a Michael addition, with SO to yield a highly emissive adduct with a marked fluorescence in the green channel (535 nm). In vitro studies showed a remarkable selectivity of photoactivated to SO with a limit of detection as low as 4.7 μM. MTT viability assays demonstrated that the is nontoxic to HeLa cells and can be used to detect SO in lysosomes. Taking advantage of this, the sensor is successfully applied to image increasing SO values in lysosomes during heat shock for the first time. Moreover, we also confirmed that the increased SO can protect the small intestine against damage induced by heat shock through regulating oxidative stress in cells and mice. Heat stroke (HS) can cause serious organism damage or even death. Early understanding of the mechanism of heat cytotoxicity can prevent or treat heat stroke related diseases. In this work, probe Ly-NT-SP was synthesized, characterized, and used for sulfur dioxide (SO2) detection in lysosomes. PBS solutions of probe Ly-NT-SP at pH 5.0 present a marked broad emission band in the green zone (535 nm). After UV irradiation, the spiropyran group in Ly-NT-SP isomerizes to the merocyanine form (Ly-NT-MR), which presented a weak red-shifted emission at 630 nm. In addition, photocontrolled isomerization of Ly-NT-SP to Ly-NT-MR generated a CC–CN+ fragment able to react, through a Michael addition, with SO2 to yield a highly emissive adduct with a marked fluorescence in the green channel (535 nm). In vitro studies showed a remarkable selectivity of photoactivated Ly-NT-MR to SO2 with a limit of detection as low as 4.7 μM. MTT viability assays demonstrated that the Ly-NT-SP is nontoxic to HeLa cells and can be used to detect SO2 in lysosomes. Taking advantage of this, the sensor is successfully applied to image increasing SO2 values in lysosomes during heat shock for the first time. Moreover, we also confirmed that the increased SO2 can protect the small intestine against damage induced by heat shock through regulating oxidative stress in cells and mice. |
| Author | Zhang, Weijie Chao, Jianbin Yin, Caixia Zhang, Yongbin Cheng, Fangqin Huo, Fangjun Yue, Yongkang |
| AuthorAffiliation | Research Institute of Applied Chemistry Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science Institute of Resources and Environmental Engineering |
| AuthorAffiliation_xml | – name: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science – name: Research Institute of Applied Chemistry – name: Institute of Resources and Environmental Engineering |
| Author_xml | – sequence: 1 givenname: Weijie surname: Zhang fullname: Zhang, Weijie organization: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science – sequence: 2 givenname: Fangjun surname: Huo fullname: Huo, Fangjun organization: Research Institute of Applied Chemistry – sequence: 3 givenname: Yongkang surname: Yue fullname: Yue, Yongkang organization: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science – sequence: 4 givenname: Yongbin surname: Zhang fullname: Zhang, Yongbin organization: Research Institute of Applied Chemistry – sequence: 5 givenname: Jianbin surname: Chao fullname: Chao, Jianbin organization: Research Institute of Applied Chemistry – sequence: 6 givenname: Fangqin surname: Cheng fullname: Cheng, Fangqin organization: Institute of Resources and Environmental Engineering – sequence: 7 givenname: Caixia orcidid: 0000-0001-5548-6333 surname: Yin fullname: Yin, Caixia email: yincx@sxu.edu.cn organization: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31951702$$D View this record in MEDLINE/PubMed |
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| Snippet | Heat stroke (HS) can cause serious organism damage or even death. Early understanding of the mechanism of heat cytotoxicity can prevent or treat heat stroke... ( )Heat stroke (HS) can cause serious organism damage or even death. Early understanding of the mechanism of heat cytotoxicity can prevent or treat heat stroke... |
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| SubjectTerms | Chemistry Chemistry, Multidisciplinary Fluorescent Dyes - chemistry HeLa Cells Hot Temperature Humans Lysosomes - metabolism Microscopy, Fluorescence - methods Oxidative Stress Physical Sciences Science & Technology Sulfur Dioxide - metabolism Ultraviolet Rays |
| Title | Heat Stroke in Cell Tissues Related to Sulfur Dioxide Level Is Precisely Monitored by Light-Controlled Fluorescent Probes |
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